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Azathioprine, cyclophosphamide, and gold have been compared under double-blind conditions in the treatment of relatively early rheumatoid arthritis. Over 18 months the two "immunosuppressive" agents produced clinical improvement comparable to that achieved with gold, and they also facilitated a reduction in the dosage of corticosteroids and retarded radiological joint deterioration. Drug management was easiest with azathioprine. Cyclophosphamide was perhaps marginally the most effective drug but it produced azoospermia in males. If the long-term hazards of malignancy and mutagenesis prove to be acceptable then the anti-proliferative agents provide a useful alternative to gold therapy and can with advantage be given relatively early in the course of rheumatoid arthritis.
H L Currey, and
J Harris, and
R M Mason, and
J Woodland, and
T Beveridge, and
C J Roberts, and
D W Vere, and
A S Dixon, and
J Davies, and
B Owen-Smith
August 1998,
British journal of rheumatology,
H L Currey, and
J Harris, and
R M Mason, and
J Woodland, and
T Beveridge, and
C J Roberts, and
D W Vere, and
A S Dixon, and
J Davies, and
B Owen-Smith
May 1975,
Polskie Archiwum Medycyny Wewnetrznej,
H L Currey, and
J Harris, and
R M Mason, and
J Woodland, and
T Beveridge, and
C J Roberts, and
D W Vere, and
A S Dixon, and
J Davies, and
B Owen-Smith
March 1977,
Arthritis and rheumatism,
H L Currey, and
J Harris, and
R M Mason, and
J Woodland, and
T Beveridge, and
C J Roberts, and
D W Vere, and
A S Dixon, and
J Davies, and
B Owen-Smith
January 1969,
Verhandlungen der Deutschen Gesellschaft fur Rheumatologie,
H L Currey, and
J Harris, and
R M Mason, and
J Woodland, and
T Beveridge, and
C J Roberts, and
D W Vere, and
A S Dixon, and
J Davies, and
B Owen-Smith
October 1982,
JAMA,
H L Currey, and
J Harris, and
R M Mason, and
J Woodland, and
T Beveridge, and
C J Roberts, and
D W Vere, and
A S Dixon, and
J Davies, and
B Owen-Smith
January 1988,
Revmatologiia (Moscow, Russia),
H L Currey, and
J Harris, and
R M Mason, and
J Woodland, and
T Beveridge, and
C J Roberts, and
D W Vere, and
A S Dixon, and
J Davies, and
B Owen-Smith
June 1988,
Clinical rheumatology,
H L Currey, and
J Harris, and
R M Mason, and
J Woodland, and
T Beveridge, and
C J Roberts, and
D W Vere, and
A S Dixon, and
J Davies, and
B Owen-Smith
December 1983,
The American journal of medicine,
H L Currey, and
J Harris, and
R M Mason, and
J Woodland, and
T Beveridge, and
C J Roberts, and
D W Vere, and
A S Dixon, and
J Davies, and
B Owen-Smith
July 1976,
Current therapeutic research, clinical and experimental,
H L Currey, and
J Harris, and
R M Mason, and
J Woodland, and
T Beveridge, and
C J Roberts, and
D W Vere, and
A S Dixon, and
J Davies, and
B Owen-Smith
May 1986,
JAMA,
