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Using a specific radioimmunoassay (RIA), we have quantitated the hypothalamic and extrahypothalamic distribution of vasoactive intestinal polypeptide (VIP) in the rat brain. Highest concentrations of VIP were found in cerebral cortex, suprachiasmatic nucleus, and medial amygdaloid nucleus. Lower concentrations were found in the anterior hypothalamic area, medial preoptic area, peri- and paraventricular nuclei, and hippocampus. Significant levels of VIP were also found in the anterior pituitary. Very little VIP was detected in median eminence and cerebellar cortex. This distribution of VIP in areas of the rat brain known to be important to neuroendocrine function suggests a role for VIP in the control of anterior pituitary events.
W K Samson, and
S I Said, and
S M McCann
August 1980,
The Journal of pharmacy and pharmacology,
W K Samson, and
S I Said, and
S M McCann
October 1994,
Neuropeptides,
W K Samson, and
S I Said, and
S M McCann
March 1992,
Brain research,
W K Samson, and
S I Said, and
S M McCann
June 1994,
Synapse (New York, N.Y.),
W K Samson, and
S I Said, and
S M McCann
January 1979,
Neuroscience,
W K Samson, and
S I Said, and
S M McCann
January 1984,
Neuropharmacology,
W K Samson, and
S I Said, and
S M McCann
February 1979,
Proceedings of the National Academy of Sciences of the United States of America,
W K Samson, and
S I Said, and
S M McCann
January 1985,
Peptides,
W K Samson, and
S I Said, and
S M McCann
January 1989,
Neuroscience,
W K Samson, and
S I Said, and
S M McCann
October 1976,
Lancet (London, England),
