BIOMAT Database Logo BIOMAT Database Logo

Hypothyroidism after thyroidectomy for Graves's disease: a search for an explanation. 1974

M Van Welsum, and T E Feltkamp, and M J De Vries, and R Doctor, and J Van Zijl, and G Hennemann

Out of 38 patients who had undergone subtotal thyroidectomy for Graves's disease seven to 20 years previously 15 developed hypothyroidism. In these 15 patients autoantibodies against thyroid cytoplasm were significantly more frequent than in the 23 euthyroid patients, though there was no difference in the prevalence of autoantibodies against thyroglobulin. Histological examination of the thyroid tissue removed at operation showed that significantly more plasma cells and lymphoid follicles with germinal centres were present in patients who subsequently developed hypothyroidism than in those who remained euthyroid. No differences in the amount of lymphocytic infiltration were seen in hypothyroid and euthyroid patients.The results suggest that B lymphocytes play a part in the development of postoperative hypothyroidism in Graves's disease. It is proposed that Graves's disease and Hashimoto's disease are different aspects of the same basic autoimmune process.

UI MeSH Term Description Entries
D007037 Hypothyroidism A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction. Central Hypothyroidism,Primary Hypothyroidism,Secondary Hypothyroidism,TSH Deficiency,Thyroid-Stimulating Hormone Deficiency,Central Hypothyroidisms,Deficiency, TSH,Deficiency, Thyroid-Stimulating Hormone,Hormone Deficiency, Thyroid-Stimulating,Hypothyroidism, Central,Hypothyroidism, Primary,Hypothyroidism, Secondary,Hypothyroidisms,Primary Hypothyroidisms,Secondary Hypothyroidisms,TSH Deficiencies,Thyroid Stimulating Hormone Deficiency,Thyroid-Stimulating Hormone Deficiencies
D008221 Lymphoid Tissue Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS. Lymphatic Tissue,Lymphatic Tissues,Lymphoid Tissues,Tissue, Lymphatic,Tissue, Lymphoid,Tissues, Lymphatic,Tissues, Lymphoid
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010950 Plasma Cells Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20) Plasmacytes,Cell, Plasma,Cells, Plasma,Plasma Cell,Plasmacyte
D003168 Complement Fixation Tests Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1. Complement Absorption Test, Conglutinating,Conglutination Reaction,Conglutinating Complement Absorption Test,Complement Fixation Test,Conglutination Reactions,Fixation Test, Complement,Fixation Tests, Complement,Reaction, Conglutination,Reactions, Conglutination,Test, Complement Fixation,Tests, Complement Fixation
D005260 Female Females
D005455 Fluorescent Antibody Technique Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy. Antinuclear Antibody Test, Fluorescent,Coon's Technique,Fluorescent Antinuclear Antibody Test,Fluorescent Protein Tracing,Immunofluorescence Technique,Coon's Technic,Fluorescent Antibody Technic,Immunofluorescence,Immunofluorescence Technic,Antibody Technic, Fluorescent,Antibody Technics, Fluorescent,Antibody Technique, Fluorescent,Antibody Techniques, Fluorescent,Coon Technic,Coon Technique,Coons Technic,Coons Technique,Fluorescent Antibody Technics,Fluorescent Antibody Techniques,Fluorescent Protein Tracings,Immunofluorescence Technics,Immunofluorescence Techniques,Protein Tracing, Fluorescent,Protein Tracings, Fluorescent,Technic, Coon's,Technic, Fluorescent Antibody,Technic, Immunofluorescence,Technics, Fluorescent Antibody,Technics, Immunofluorescence,Technique, Coon's,Technique, Fluorescent Antibody,Technique, Immunofluorescence,Techniques, Fluorescent Antibody,Techniques, Immunofluorescence,Tracing, Fluorescent Protein,Tracings, Fluorescent Protein
D006111 Graves Disease A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy). Basedow's Disease,Exophthalmic Goiter,Goiter, Exophthalmic,Graves' Disease,Basedow Disease,Hyperthyroidism, Autoimmune,Basedows Disease,Disease, Basedow,Disease, Basedow's,Disease, Graves,Disease, Graves',Exophthalmic Goiters,Goiters, Exophthalmic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

M Van Welsum, and T E Feltkamp, and M J De Vries, and R Doctor, and J Van Zijl, and G Hennemann
Thyrotoxic Graves's disease after primary hypothyroidism.
September 1978, British medical journal,
M Van Welsum, and T E Feltkamp, and M J De Vries, and R Doctor, and J Van Zijl, and G Hennemann
Thyrotoxic Graves's disease after primary hypothyroidism.
October 1978, British medical journal,
M Van Welsum, and T E Feltkamp, and M J De Vries, and R Doctor, and J Van Zijl, and G Hennemann
Thyrotoxic Graves's disease after primary hypothyroidism.
November 1978, British medical journal,
M Van Welsum, and T E Feltkamp, and M J De Vries, and R Doctor, and J Van Zijl, and G Hennemann
Residual symptoms in Graves's disease after thyroidectomy.
June 1948, Lancet (London, England),
M Van Welsum, and T E Feltkamp, and M J De Vries, and R Doctor, and J Van Zijl, and G Hennemann
Hypothyroidism after thyroidectomy for Graves' disease.
November 1981, American journal of surgery,
M Van Welsum, and T E Feltkamp, and M J De Vries, and R Doctor, and J Van Zijl, and G Hennemann
Hypothyroidism after thyroidectomy.
November 1976, Lancet (London, England),
M Van Welsum, and T E Feltkamp, and M J De Vries, and R Doctor, and J Van Zijl, and G Hennemann
[Hypothyroidism after thyroidectomy for nontoxic goiter].
September 1970, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
M Van Welsum, and T E Feltkamp, and M J De Vries, and R Doctor, and J Van Zijl, and G Hennemann
Thyroidectomy for Graves' disease: is hypothyroidism inevitable?
March 1989, Annals of the Royal College of Surgeons of England,
M Van Welsum, and T E Feltkamp, and M J De Vries, and R Doctor, and J Van Zijl, and G Hennemann
Prediction of hypothyroidism after partial thyroidectomy for thyrotoxicosis.
January 1972, British medical journal,
M Van Welsum, and T E Feltkamp, and M J De Vries, and R Doctor, and J Van Zijl, and G Hennemann
Prevention and management of hypothyroidism after thyroidectomy for thyrotoxicosis.
May 1978, World journal of surgery,
Copied contents to your clipboard!