Biomaterial Database

Comparison of "Duphalac" and "irritant" laxatives during and after treatment of chronic constipation: a preliminary study. 1974

P Connolly, and I W Hughes, and G Ryan

A multi-centre trial was carried out to compare the effectiveness in the treatment of chronic constipation of a lactulose preparation ("Duphalac") and "irritant" laxatives containing senna, anthraquinone derivatives or bisacodyl. The results, in 164 patients, indicate that the lactulose prepartion was more effective than the "irritant" laxatives. By Day 7, 58% of the lactulose-treated group were passing a normal stool whereas only 42% of the patients receiving an "irritant" laxative did so at the same stage in treatment. The lactulose preparation was shown to have a persistent CARRY-OVER" EFFECT, AND THIS EFFECT WAS SEEN IN SIGNIFICANTLY MORE PATIENTS RECEIVING "Duphalac" than in the "irritant" laxative group.

UI	MeSH Term	Description	Entries
D007792	Lactulose	A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887)	Amivalex,Duphalac,Normase
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D001726	Bisacodyl	A diphenylmethane stimulant laxative used for the treatment of CONSTIPATION and for bowel evacuation. (From Martindale, The Extra Pharmacopoeia, 30th ed, p871)	Agaroletten,Apo-Bisacodyl,Bekunis Bisacodyl,Bicol,Bisac-Evac,Bisacodyl Tannex,Bisacodyl Uniserts,Bisalax,Bisco-Lax,Bisco-Zitron,Dulco-Lax,Dulco-lax perles,Dulcolax,Durolax,Fleet Bisacodyl,Florisan N,Laxagetten,Laxanin,Laxans-ratiopharm,Laxbene,Laxysat Bürger,Lünolax,Rytmil,Ulcolax,ratio-Bisacodyl,Apo Bisacodyl,Bisac Evac,Bisacodyl, Bekunis,Bisacodyl, Fleet,Bisco Lax,Bisco Zitron,Dulco Lax,Dulco lax perles,Dulcolax perles,Laxans ratiopharm,Tannex, Bisacodyl,Uniserts, Bisacodyl,ratio Bisacodyl
D002400	Cathartics	Agents that are used to stimulate evacuation of the bowels.	Bowel Evacuant,Bowel Preparation Solution,Cathartic,Purgative,Purgatives,Bowel Evacuants,Bowel Preparation Solutions,Evacuant, Bowel,Evacuants, Bowel,Preparation Solution, Bowel,Preparation Solutions, Bowel,Solution, Bowel Preparation,Solutions, Bowel Preparation
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D002908	Chronic Disease	Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D003248	Constipation	Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.	Colonic Inertia,Dyschezia
D004187	Disaccharides	Oligosaccharides containing two monosaccharide units linked by a glycosidic bond.	Disaccharide