Biomaterial Database

Distribution of [3H]prednisolone entrapped in lipid layer of liposome after intramuscular administration in rats. 1979

S Shinozawa, and Y Araki, and T Oda

Positivery charged, sonicated liposome entrapping [3H]prednisolone was administered into the rats hip muscle to examine its absorption and distribution in comparison with that of the administration of free [3H]prednisolone. Plasma concentration of prednisolone in liposome-entrapped form showed high concentration for a long period of time, the values being 8 times after 30 min and 24 times after 24 hr compared to the free form. The concentration of liposome-entrapped form in liver, kidney and spleen was 4-10 times, and in lung and pancreas was 8-10 times higher than that of free form after 30 min and 24 hr. But, in adrenal, after 30 min and 1 hr, liposome-entrapped form were lower than that of free form, the former remained longer in the tissue, and the concentration maintained the high level after 24 hr, being about 28 times higher than that of free form. Even in the duodenum and large intestine, absorption of the liposome-entrapped form was very active and remained in the tissue for a long period of time. These facts suggested the possibility of using a small dose in intramuscular administration but allowing the steroid to remain in the tissues for a long period of time.

UI	MeSH Term	Description	Entries
D007273	Injections, Intramuscular	Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.	Intramuscular Injections,Injection, Intramuscular,Intramuscular Injection
D008081	Liposomes	Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.	Niosomes,Transferosomes,Ultradeformable Liposomes,Liposomes, Ultra-deformable,Liposome,Liposome, Ultra-deformable,Liposome, Ultradeformable,Liposomes, Ultra deformable,Liposomes, Ultradeformable,Niosome,Transferosome,Ultra-deformable Liposome,Ultra-deformable Liposomes,Ultradeformable Liposome
D008297	Male		Males
D011239	Prednisolone	A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.	Di-Adreson-F,Predate,Predonine,Di Adreson F,DiAdresonF
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D014018	Tissue Distribution	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.	Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D050356	Lipid Metabolism	Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.	Metabolism, Lipid
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus