Biomaterial Database

Coenzyme Q10 or alpha-tocopherol reduce the acute toxicity of anthramycin in mice. 1979

W C Lubawy, and J Whaley, and L H Hurley

Pretreatment for 4 days with 10 mg/kg coenzyme Q10 (CoQ) or 1 day with 85U alpha-tocopherol (Vit E) produced equal reduction in the acute toxicity of 0.5 mg/kg anthramycin (ANTH). Twenty-seven days after ANTH, 40 percent of control mice survived, those pretreated with CoQ or Vit E displayed 73 and 80 percent survival. A 17.5 mg/kg dose of adriamycin (ADR) produced a percent survival-time curve resembling that produced by 0.5 mg/kg ANTH. At this dose of ADR, however, the protection afforded by CoQ and Vit E was minimal and not statistically significant (p less than 0.05). CoQ or Vit E may be of value at reducing the toxicity of anticancer agents other than the anthracyclines.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D004317	Doxorubicin	Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.	Adriamycin,Adriablastin,Adriablastine,Adriblastin,Adriblastina,Adriblastine,Adrimedac,DOXO-cell,Doxolem,Doxorubicin Hexal,Doxorubicin Hydrochloride,Doxorubicin NC,Doxorubicina Ferrer Farm,Doxorubicina Funk,Doxorubicina Tedec,Doxorubicine Baxter,Doxotec,Farmiblastina,Myocet,Onkodox,Ribodoxo,Rubex,Urokit Doxo-cell,DOXO cell,Hydrochloride, Doxorubicin,Urokit Doxo cell
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000876	Anthramycin	A broad-spectrum spectrum antineoplastic antibiotic isolated from Streptomyces refuineus var. thermotolerans. It has low toxicity, some activity against Trichomonas and Endamoeba, and inhibits RNA and DNA synthesis. It binds irreversibly to DNA.	Anthramycin, (11a alpha)-Isomer,Antramycin
D001570	Benzodiazepinones
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D014451	Ubiquinone	A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals.	Coenzyme Q
D014810	Vitamin E	A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus