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We investigated in dogs the effect of graded frequencies of electrical vagal stimulation (1.5, 3, 6, and 12 cps) on pancreatic exocrine secretion and on portal blood levels of gastrin, secretin, cholecystokinin (CCK), vasoactive intestinal peptide (VIP), and somatostatin (STS). Stimuli of all four frequencies, each with a duration of 5 minutes, were applied with a secretin background of 0.25 CU/kg-hr, and one stimulatory period of 12 cps was applied without a secretin background. With secretin, a significant, frequency-dependent increase of volume and of pancreatic protein secretion occurred from 3 to 12 cps. Gastrin values increased significantly at all frequencies. VIP and STS increased significantly with 3, 6, and 12 cps. Maximal responses for gastrin, VIP, and STS were observed with 6 cps. Peak values for gastrin and VIP were found during stimulation, whereas STS peaked after the end of the stimulatory period. The integrated responses of gastrin and STS showed significant correlation (P less than 0.01). The results suggest that vagally induced pancreatic response is only partially mediated by gastrin and perhaps VIP, and that endogenous gastrin may be one of the releasing factors for somatostatin. Plasma levels of CCK and secretin did not change after electrical stimulation, which provides direct evidence that their release is unlikely to be under vagal control, and that CCK does not mediate the protein secretion obtained after electrical stimulation of the vagus.
S Guzman, and
J A Chayvialle, and
W A Banks, and
P L Rayford, and
J C Thompson
February 1976,
The Journal of physiology,
S Guzman, and
J A Chayvialle, and
W A Banks, and
P L Rayford, and
J C Thompson
May 1984,
Gastroenterology,
S Guzman, and
J A Chayvialle, and
W A Banks, and
P L Rayford, and
J C Thompson
January 1987,
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology,
S Guzman, and
J A Chayvialle, and
W A Banks, and
P L Rayford, and
J C Thompson
October 1987,
Digestive diseases and sciences,
S Guzman, and
J A Chayvialle, and
W A Banks, and
P L Rayford, and
J C Thompson
June 1975,
Gastroenterology,
S Guzman, and
J A Chayvialle, and
W A Banks, and
P L Rayford, and
J C Thompson
January 1983,
The Japanese journal of physiology,
S Guzman, and
J A Chayvialle, and
W A Banks, and
P L Rayford, and
J C Thompson
January 1990,
Acta chirurgica Scandinavica. Supplementum,
S Guzman, and
J A Chayvialle, and
W A Banks, and
P L Rayford, and
J C Thompson
March 1990,
The American journal of physiology,
S Guzman, and
J A Chayvialle, and
W A Banks, and
P L Rayford, and
J C Thompson
October 1986,
Annals of internal medicine,
S Guzman, and
J A Chayvialle, and
W A Banks, and
P L Rayford, and
J C Thompson
October 1986,
Brain research,
