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Sixteen patients with advanced gastrointestinal cancer (colorectal 12/16, gastric 4/16) were treated with a combination of 5-fluorouracil (5-FU) plus 1-(2-chlorethyl)-3(4-methyl-cycloexyl)-1-nitrosourea (Me-CCNU). The therapeutic program consisted of orally administered Me-CCNU (140 mg/m2) and intravenous 5-FU (9.5 mg/kg by bolus injection for 5 days). The cycles were repeated at 6-week intervals. At the beginning of the therapy, 11/16 patients were in performance status (PS) 0-1 and 5 patients in PS 2-3. Eight patients developed early progressive disease between the 1st and 2nd course of therapy. Only a minor tumor response was observed in the remaining 50% of the patients. However, the patients with stabilized disease lived longer (11.8 months) than non-responders (3.5 months).
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A M Liberati, and
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G Fatati, and
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F Grignani
October 1978,
Cancer treatment reports,
A Brutti, and
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Acta gastroenterologica Latinoamericana,
A Brutti, and
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January 1980,
Cancer treatment reports,
A Brutti, and
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February 1983,
Journal of surgical oncology,
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September 1977,
Clinical oncology,
A Brutti, and
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January 1981,
Oncology,
A Brutti, and
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F Grignani
January 1981,
Medical and pediatric oncology,
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June 1976,
Cancer treatment reports,
