BIOMAT Database Logo BIOMAT Database Logo

Metabolism of third complement component (C3) in nephritis. Involvement of the classic and alternate (properdin) pathways for complement activation. 1972

L G Hunsicker, and S Ruddy, and C B Carpenter, and P H Schur, and J P Merrill, and H J Müller-Eberhard, and K F Austen

UI MeSH Term Description Entries
D007122 Immunoelectrophoresis A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
D007456 Iodine Isotopes Stable iodine atoms that have the same atomic number as the element iodine, but differ in atomic weight. I-127 is the only naturally occurring stable iodine isotope. Isotopes, Iodine
D008180 Lupus Erythematosus, Systemic A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009393 Nephritis Inflammation of any part of the KIDNEY. Nephritides
D011414 Properdin A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections. Complement Factor P,Factor P, Complement
D011485 Protein Binding The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments. Plasma Protein Binding Capacity,Binding, Protein
D002908 Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D003165 Complement System Proteins Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY). Complement Proteins,Complement,Complement Protein,Hemolytic Complement,Complement, Hemolytic,Protein, Complement,Proteins, Complement,Proteins, Complement System

Related Publications

L G Hunsicker, and S Ruddy, and C B Carpenter, and P H Schur, and J P Merrill, and H J Müller-Eberhard, and K F Austen
Complement activation in semi-solid medium: Insolubilization of properdin and the third component of complement (C3) in agar gels.
January 1976, Journal of immunology (Baltimore, Md. : 1950),
L G Hunsicker, and S Ruddy, and C B Carpenter, and P H Schur, and J P Merrill, and H J Müller-Eberhard, and K F Austen
Analysis of the interactions between properdin, the third component of complement (C3), and its physiological activation products.
May 1988, The Biochemical journal,
L G Hunsicker, and S Ruddy, and C B Carpenter, and P H Schur, and J P Merrill, and H J Müller-Eberhard, and K F Austen
Activation of the classic and alternate complement pathways by endotoxin.
February 1974, Journal of immunology (Baltimore, Md. : 1950),
L G Hunsicker, and S Ruddy, and C B Carpenter, and P H Schur, and J P Merrill, and H J Müller-Eberhard, and K F Austen
[The third component of complement, C3].
November 1999, Nihon rinsho. Japanese journal of clinical medicine,
L G Hunsicker, and S Ruddy, and C B Carpenter, and P H Schur, and J P Merrill, and H J Müller-Eberhard, and K F Austen
Metabolism of the third component of complement (C3) in normal human subjects.
February 1974, Clinical science and molecular medicine,
L G Hunsicker, and S Ruddy, and C B Carpenter, and P H Schur, and J P Merrill, and H J Müller-Eberhard, and K F Austen
Third component of human complement: C3.
January 1990, Methods in enzymology,
L G Hunsicker, and S Ruddy, and C B Carpenter, and P H Schur, and J P Merrill, and H J Müller-Eberhard, and K F Austen
The role of properdin in the alternate pathway of complement activation.
January 1974, The Journal of experimental medicine,
L G Hunsicker, and S Ruddy, and C B Carpenter, and P H Schur, and J P Merrill, and H J Müller-Eberhard, and K F Austen
Metabolism of the third component of complement (C3) in patients with rheumatoid arthritis.
January 1972, Arthritis and rheumatism,
L G Hunsicker, and S Ruddy, and C B Carpenter, and P H Schur, and J P Merrill, and H J Müller-Eberhard, and K F Austen
The utilization of properdin in the alternate pathway of complement activation: isolation of properdin convertase.
January 1974, Journal of immunology (Baltimore, Md. : 1950),
L G Hunsicker, and S Ruddy, and C B Carpenter, and P H Schur, and J P Merrill, and H J Müller-Eberhard, and K F Austen
Covalent linkage of C3 to properdin during complement activation.
May 1995, European journal of immunology,
Copied contents to your clipboard!