Biomaterial Database

Distribution of neuraminidase and n-acetylneuraminate lyase activities among corynebacteria, mycobacteria, and nocardias. 1972

S B Arden, and W H Chang, and L Barksdale

In Corynebacterium diphtheriae and closely related neuraminidase-producing corynebacteria, we have found an N-acetylneuraminate (NAN) lyase activity which cleaves NAN into N-acetyl-d-mannosamine and, presumably, pyruvate. In vitro, these lyases can be shown to synthesize NAN. A survey of representative corynebacteria, "plant pathogenic corynebacteria," mycobacteria, and nocardias revealed that only those corynebacteria closely related to C. diphtheriae exhibited both neuraminidase and NAN lyase activities.

UI	MeSH Term	Description	Entries
D007652	Oxo-Acid-Lyases	Enzymes that catalyze the cleavage of a carbon-carbon bond of a 3-hydroxy acid. (Dorland, 28th ed) EC 4.1.3.	Ketoacid-Lyases,Ketoacid Lyases,Oxo Acid Lyases
D008358	Mannose	A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)	D-Mannose,Mannopyranose,Mannopyranoside,D Mannose
D009161	Mycobacterium	A genus of gram-positive, aerobic bacteria. Most species are free-living in soil and water, but the major habitat for some is the diseased tissue of warm-blooded hosts.	Mycobacteria
D009163	Mycobacterium bovis	The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis.	BCG,Calmette-Guerin Bacillus
D009169	Mycobacterium tuberculosis	A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.	Mycobacterium tuberculosis H37Rv
D009438	Neuraminic Acids	Nine-carbon deoxyamino SUGAR ACIDS that are substrates for NEURAMINIDASE. Their derivatives include SIALIC ACIDS.	Acids, Neuraminic
D009439	Neuraminidase	An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)	Sialidase,Exo-alpha-Sialidase,N-Acylneuraminate Glycohydrolases,Oligosaccharide Sialidase,Exo alpha Sialidase,Glycohydrolases, N-Acylneuraminate,N Acylneuraminate Glycohydrolases,Sialidase, Oligosaccharide
D009615	Nocardia	A genus of gram-positive, aerobic bacteria whose species are widely distributed and are abundant in soil. Some strains are pathogenic opportunists for humans and animals.	Micropolyspora
D009616	Nocardia asteroides	A species of bacterium of the family NOCARDIACEAE, producing pulmonary infections in man.
D011773	Pyruvates	Derivatives of PYRUVIC ACID, including its salts and esters.

Related Publications

S B Arden, and W H Chang, and L Barksdale

Neuraminidase and N-acetylneuraminate pyruvate-lyase of Pasteurella multocida.

September 1972, Journal of general microbiology,

S B Arden, and W H Chang, and L Barksdale

Chemical and antigenic studies on cell walls of mycobacteria, corynebacteria, and nocardias.

December 1965, The American review of respiratory disease,

S B Arden, and W H Chang, and L Barksdale

[Incidence and significance of neuraminidase and N-acetylneuraminate-pyruvate-lyase in various animal Haemophilus species].

July 1978, Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B,

S B Arden, and W H Chang, and L Barksdale

[The occurrence of neuraminidase and N-acetylneuraminate-pyruvate lyase in pathogenic haemophili of man (author's transl)].

October 1977, Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,

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The reaction of N-acetylneuraminate lyase with chloropyruvate.

November 1974, The Biochemical journal,

S B Arden, and W H Chang, and L Barksdale

[DNA content of Mycobacteria and Nocardias].

June 1969, Kekkaku : [Tuberculosis],

S B Arden, and W H Chang, and L Barksdale

Number and function of sulphydryl groups of N-acetylneuraminate lyase.

June 1985, Archives internationales de physiologie et de biochimie,

S B Arden, and W H Chang, and L Barksdale

Occurrence of sialidase and N-acetylneuraminate lyase in Pasteurella species.

November 1995, Zentralblatt fur Bakteriologie : international journal of medical microbiology,