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12% of the rectal biopsies (19% of the patients) showed epitheloid cell granulomas in clinically definite Crohn's disease. In colonic biopsies such granulomata were visible in 14% (22% of the patients). Granulomata were scarcely seen in normal or slightly inflamed mucosa. They were mostly found together with crypt abscesses and/or erosions and ulcers. The combination of local inflammation around crypts and crypt abscesses is rather characteristic for Crohn's disease. The inflammatory colonic alterations, visible in crohon's disease, may have the following pathogenetic sequence: Local colitis-crypt abscess--destruction of the crypt with proliferation of enlarged histiocytes--transformation histiocytes to epitheloid cells and Langhans cells--epitheloid cell granuloma.
P Schmitz-Moormann, and
H Malchow, and
B Miller, and
J W Brandes
July 1981,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
P Schmitz-Moormann, and
H Malchow, and
B Miller, and
J W Brandes
January 1981,
Sbornik lekarsky,
P Schmitz-Moormann, and
H Malchow, and
B Miller, and
J W Brandes
March 1977,
Klinische Wochenschrift,
P Schmitz-Moormann, and
H Malchow, and
B Miller, and
J W Brandes
August 1976,
Nippon Ganka Gakkai zasshi,
P Schmitz-Moormann, and
H Malchow, and
B Miller, and
J W Brandes
July 1974,
Ceskoslovenska gastroenterologie a vyziva,
P Schmitz-Moormann, and
H Malchow, and
B Miller, and
J W Brandes
January 1984,
Zeitschrift fur arztliche Fortbildung,
P Schmitz-Moormann, and
H Malchow, and
B Miller, and
J W Brandes
October 1980,
Kekkaku : [Tuberculosis],
P Schmitz-Moormann, and
H Malchow, and
B Miller, and
J W Brandes
March 1975,
Ceskoslovenska radiologie,
P Schmitz-Moormann, and
H Malchow, and
B Miller, and
J W Brandes
September 1977,
Ceskoslovenska radiologie,
P Schmitz-Moormann, and
H Malchow, and
B Miller, and
J W Brandes
February 1979,
Nihon Jibiinkoka Gakkai kaiho,
