-transparent.png){kind=logo}
The procoagulant material of lymphocytes has been characterized as tissue factor. Lymphocytes stimulated with phytohemagglutinin or the purified protein derivative of the tubercle bacillus developed procoagulant activity with incubation in tissue culture. While this material corrected the prolonged clotting time of factor VIII (AHF) deficient plasma, we have shown, utilizing a sensitive radioimmunoassay, that no AHF antigen was present in the cell cultures. Further, we have demonstrated this material to be tissue factor by coagulation techniques and immunological cross-reactivity. The published data regarding factor VIII synthesis is reviewed in light of these observations and comments are made regarding the role of the lymphocyte procoagulant.
F R Rickles, and
J A Hardin, and
F A Pitlick, and
L W Hoyer, and
M E Conrad
March 1996,
American journal of hematology,
F R Rickles, and
J A Hardin, and
F A Pitlick, and
L W Hoyer, and
M E Conrad
April 2009,
Genetic testing and molecular biomarkers,
F R Rickles, and
J A Hardin, and
F A Pitlick, and
L W Hoyer, and
M E Conrad
April 1980,
Blut,
F R Rickles, and
J A Hardin, and
F A Pitlick, and
L W Hoyer, and
M E Conrad
November 1963,
Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete,
F R Rickles, and
J A Hardin, and
F A Pitlick, and
L W Hoyer, and
M E Conrad
August 1959,
Experimental cell research,
F R Rickles, and
J A Hardin, and
F A Pitlick, and
L W Hoyer, and
M E Conrad
November 2002,
Journal of immunological methods,
F R Rickles, and
J A Hardin, and
F A Pitlick, and
L W Hoyer, and
M E Conrad
May 1996,
Annals of hematology,
F R Rickles, and
J A Hardin, and
F A Pitlick, and
L W Hoyer, and
M E Conrad
February 1975,
Immunology,
F R Rickles, and
J A Hardin, and
F A Pitlick, and
L W Hoyer, and
M E Conrad
October 1972,
Cancer,
F R Rickles, and
J A Hardin, and
F A Pitlick, and
L W Hoyer, and
M E Conrad
July 1996,
Thrombosis and haemostasis,
