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The physician population delivering obstetric care in Philadelphia between 1950 and 1970 was contacted to ascertain their use of diethylstilbesterol (DES) during pregnancy. Of the 31.8% of the physicians who responded to the questionnaire, 71.8% used DES during pregnancy and 12.7% desired assistance in review of their records. During the 6 years from the initial survey, 830 young women exposed to DES in utero were periodically screened for cervicovaginal abnormalities and clear cell adenocarcinoma. Of these 830 patients 61.7% were found to have cervicovaginal abnormalities, and 65.9% of the patients showed either adenosis or evidence of the prior existence of vaginal adenosis. Eight patients were treated for clear cell adenocarcinoma. Two cases were detected while asymptomatic. Seven of the patients are living with no evidence of cancer, and two of these have survived over 5 years.
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R L Guintoli, and
T V Sedlacek, and
T Rocereto, and
E Rubin, and
M Burtnett, and
J J Mikuta
September 1979,
Clinical obstetrics and gynecology,
C E Mangan, and
R L Guintoli, and
T V Sedlacek, and
T Rocereto, and
E Rubin, and
M Burtnett, and
J J Mikuta
August 1984,
Canadian family physician Medecin de famille canadien,
C E Mangan, and
R L Guintoli, and
T V Sedlacek, and
T Rocereto, and
E Rubin, and
M Burtnett, and
J J Mikuta
December 1972,
Obstetrics and gynecology,
C E Mangan, and
R L Guintoli, and
T V Sedlacek, and
T Rocereto, and
E Rubin, and
M Burtnett, and
J J Mikuta
May 1981,
Pediatric clinics of North America,
C E Mangan, and
R L Guintoli, and
T V Sedlacek, and
T Rocereto, and
E Rubin, and
M Burtnett, and
J J Mikuta
October 1952,
Archivos del Instituto de Cardiologia de Mexico,
C E Mangan, and
R L Guintoli, and
T V Sedlacek, and
T Rocereto, and
E Rubin, and
M Burtnett, and
J J Mikuta
October 1971,
Ceskoslovenska otolaryngologie,
C E Mangan, and
R L Guintoli, and
T V Sedlacek, and
T Rocereto, and
E Rubin, and
M Burtnett, and
J J Mikuta
September 1971,
The Journal of endocrinology,
C E Mangan, and
R L Guintoli, and
T V Sedlacek, and
T Rocereto, and
E Rubin, and
M Burtnett, and
J J Mikuta
January 2012,
Qatar medical journal,
C E Mangan, and
R L Guintoli, and
T V Sedlacek, and
T Rocereto, and
E Rubin, and
M Burtnett, and
J J Mikuta
July 1984,
Fertility and sterility,
C E Mangan, and
R L Guintoli, and
T V Sedlacek, and
T Rocereto, and
E Rubin, and
M Burtnett, and
J J Mikuta
December 1990,
Clinical nuclear medicine,
