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Endometrial carcinomas from 58 patients were graded histologically, and the histologic grade was compared with the estrogen and progesterone receptor content of the tumor tissues. Receptor content was determined by multiple concentration saturation analysis and sucrose density gradient analysis. A positive correlation was found between the presence of estrogen and progesterone receptors and the degree of tumor differentiation. The majority (85%) of well-differentiated lesions contained significant amounts of both steroid receptor proteins. In contrast, only 13% of the poorly differentiated lesions were characterized by the presence of detectable levels of both estrogen and progesterone receptor proteins. The relationship of receptor content and degree of differentiation to prognosis and potential for response to hormonal therapy is discussed.
K S McCarty, and
T K Barton, and
B F Fetter, and
W T Creasman, and
K S McCarty
September 1986,
Cancer,
K S McCarty, and
T K Barton, and
B F Fetter, and
W T Creasman, and
K S McCarty
October 1976,
Israel journal of medical sciences,
K S McCarty, and
T K Barton, and
B F Fetter, and
W T Creasman, and
K S McCarty
July 1997,
Zhonghua fu chan ke za zhi,
K S McCarty, and
T K Barton, and
B F Fetter, and
W T Creasman, and
K S McCarty
April 1992,
The Journal of steroid biochemistry and molecular biology,
K S McCarty, and
T K Barton, and
B F Fetter, and
W T Creasman, and
K S McCarty
July 2003,
Sao Paulo medical journal = Revista paulista de medicina,
K S McCarty, and
T K Barton, and
B F Fetter, and
W T Creasman, and
K S McCarty
March 2000,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
K S McCarty, and
T K Barton, and
B F Fetter, and
W T Creasman, and
K S McCarty
January 1985,
Orvosi hetilap,
K S McCarty, and
T K Barton, and
B F Fetter, and
W T Creasman, and
K S McCarty
April 2005,
American journal of clinical pathology,
K S McCarty, and
T K Barton, and
B F Fetter, and
W T Creasman, and
K S McCarty
April 1980,
The Journal of reproductive medicine,
K S McCarty, and
T K Barton, and
B F Fetter, and
W T Creasman, and
K S McCarty
July 1983,
Journal of steroid biochemistry,
