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Tight junctions of normal human epithelium comprise 6--8 intramembranous ridges. Tight junctions of adenomas and one case of follicular carcinoma were morphologically identical with normal controls. Another follicular carcinoma (clinically less malignant than the case mentioned above), however, showed loss of junctional polarity with spreading of ridges on lateral cell membranes. One case of papillary carcinoma (clinically low malignancy) displayed only focal attenuations of the tight junction belt. Another more malignant tumor of the same histologic type showed breaks of ridges and focal interruptions of the tight junction meshwork. Cell membranes of two anaplastic carcinomas of high malignancy were completely devoid of tight junction ridges. We conclude that tight junction alterations are not necessarily implicated in malignant transformation and that they correspond with tumor differentiation rather than directly with a single parameter of thyroid tumor malignancy.
D Kerjaschki, and
K Krisch, and
U B Sleyter, and
W Umrath, and
R Jakesz, and
D Depisch, and
R Kokoschka, and
H Hörandner
January 1998,
Ultrastructural pathology,
D Kerjaschki, and
K Krisch, and
U B Sleyter, and
W Umrath, and
R Jakesz, and
D Depisch, and
R Kokoschka, and
H Hörandner
March 1983,
Journal of ultrastructure research,
D Kerjaschki, and
K Krisch, and
U B Sleyter, and
W Umrath, and
R Jakesz, and
D Depisch, and
R Kokoschka, and
H Hörandner
January 1982,
Anatomy and embryology,
D Kerjaschki, and
K Krisch, and
U B Sleyter, and
W Umrath, and
R Jakesz, and
D Depisch, and
R Kokoschka, and
H Hörandner
July 1985,
Endocrinology,
D Kerjaschki, and
K Krisch, and
U B Sleyter, and
W Umrath, and
R Jakesz, and
D Depisch, and
R Kokoschka, and
H Hörandner
January 1977,
Tissue & cell,
D Kerjaschki, and
K Krisch, and
U B Sleyter, and
W Umrath, and
R Jakesz, and
D Depisch, and
R Kokoschka, and
H Hörandner
January 2003,
Methods in molecular medicine,
D Kerjaschki, and
K Krisch, and
U B Sleyter, and
W Umrath, and
R Jakesz, and
D Depisch, and
R Kokoschka, and
H Hörandner
January 2003,
Methods in molecular medicine,
D Kerjaschki, and
K Krisch, and
U B Sleyter, and
W Umrath, and
R Jakesz, and
D Depisch, and
R Kokoschka, and
H Hörandner
April 1992,
American journal of respiratory cell and molecular biology,
D Kerjaschki, and
K Krisch, and
U B Sleyter, and
W Umrath, and
R Jakesz, and
D Depisch, and
R Kokoschka, and
H Hörandner
January 1989,
Acta anatomica,
D Kerjaschki, and
K Krisch, and
U B Sleyter, and
W Umrath, and
R Jakesz, and
D Depisch, and
R Kokoschka, and
H Hörandner
August 1979,
Journal of ultrastructure research,
