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The present study examines the possibility of correlation between free serum and urinary total hydroxyproline and whether this correlation can be applied to clinical conditions. The correlation between the two indices was 0.80 (P less than 0.001) in 18 patients, mostly suffering from malignant disease. On comparing the same measurements in 37 patients, all with known metastatic bone disease, we found 29/37 normal results for free serum hydroxyproline, whereas only 2/37 values of urinary total hydroxyproline were normal. The authors therefore conclude that urinary total hydroxyproline, measured as the ratio hydroxyproline/creatinine in a fresh specimen of early-morning urine, is the best index of collagen breakdown in metastatic bone disease and preferable to measurement of free serum hydroxyproline.
A B Gasser, and
D Depierre, and
B Courvoisier
December 1967,
Nihon Seikeigeka Gakkai zasshi,
A B Gasser, and
D Depierre, and
B Courvoisier
August 1964,
The New England journal of medicine,
A B Gasser, and
D Depierre, and
B Courvoisier
January 1976,
Acta medica Polona,
A B Gasser, and
D Depierre, and
B Courvoisier
January 1975,
Physiologie (Bucarest),
A B Gasser, and
D Depierre, and
B Courvoisier
October 1981,
Archives of internal medicine,
A B Gasser, and
D Depierre, and
B Courvoisier
March 1983,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
A B Gasser, and
D Depierre, and
B Courvoisier
February 1973,
The Journal of the Association of Physicians of India,
A B Gasser, and
D Depierre, and
B Courvoisier
June 1982,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
A B Gasser, and
D Depierre, and
B Courvoisier
December 1991,
Clinica chimica acta; international journal of clinical chemistry,
A B Gasser, and
D Depierre, and
B Courvoisier
January 1984,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
