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Methylation of chromatin DNA in rat liver cell nuclei incubated in a medium with [3H]CH3-S-adenosyl methionine was studied. It was shown that under the given experimental conditions DNA methylation and chromatin degradation by endogenous nuclear nuclease (nucleases) with a formation of chromatin structural subunits occur simultaneously. An analysis of methylated chromatin DNA degradation products based on a number of approaches demonstrated a predominant methylation of extra-nucleosomal DNA. The data obtained suggest that chromatin of isolated nuclei contain sites with supermethylated DNA fragments incorporating not less than 400 nucleotide pairs. These sites possess an increased sensitivity to endogenous nuclease.
N N Khodarev, and
I I Votrin, and
N N Sokolov, and
A G Basnak'ian
August 1979,
Molecular biology reports,
N N Khodarev, and
I I Votrin, and
N N Sokolov, and
A G Basnak'ian
January 1968,
Folia biologica,
N N Khodarev, and
I I Votrin, and
N N Sokolov, and
A G Basnak'ian
January 1976,
Voprosy meditsinskoi khimii,
N N Khodarev, and
I I Votrin, and
N N Sokolov, and
A G Basnak'ian
January 1976,
Doklady Akademii nauk SSSR,
N N Khodarev, and
I I Votrin, and
N N Sokolov, and
A G Basnak'ian
February 1977,
Biochimica et biophysica acta,
N N Khodarev, and
I I Votrin, and
N N Sokolov, and
A G Basnak'ian
January 1984,
Anticancer research,
N N Khodarev, and
I I Votrin, and
N N Sokolov, and
A G Basnak'ian
November 1985,
Biochemical pharmacology,
N N Khodarev, and
I I Votrin, and
N N Sokolov, and
A G Basnak'ian
March 1983,
Cancer letters,
N N Khodarev, and
I I Votrin, and
N N Sokolov, and
A G Basnak'ian
September 1967,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
N N Khodarev, and
I I Votrin, and
N N Sokolov, and
A G Basnak'ian
January 1990,
Cytobios,
