Does obstructive jaundice adversely affect wound healing? 1979

M G Greaney, and R Van Noort, and A Smythe, and T T Irvin

The effect of obstructive jaundice on wound healing has been investigated in an experimental study of abdominal wounds in rats following ligation and division of the common bile duct. Animals were jaundiced for 2 weeks before a second operation at which the abdominal wounds were made. The wounds in jaundiced and control animals showed no significant differences in mechanical strength during a 21-day period of study but there was a significant delay in the accumulation of collagen in the wounds of jaundiced animals. The findings suggest that the biochemical changes in the wounds of jaundiced animals did not interfere with wound repair and cast doubt on the thesis that jaundice has an adverse effect on wound healing.

UI MeSH Term Description Entries
D008297 Male Males
D002779 Cholestasis Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS). Bile Duct Obstruction,Biliary Stasis,Bile Duct Obstructions,Biliary Stases,Cholestases,Duct Obstruction, Bile,Duct Obstructions, Bile,Obstruction, Bile Duct,Obstructions, Bile Duct,Stases, Biliary,Stasis, Biliary
D003094 Collagen A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH). Avicon,Avitene,Collagen Felt,Collagen Fleece,Collagenfleece,Collastat,Dermodress,Microfibril Collagen Hemostat,Pangen,Zyderm,alpha-Collagen,Collagen Hemostat, Microfibril,alpha Collagen
D000005 Abdomen That portion of the body that lies between the THORAX and the PELVIS. Abdomens
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013718 Tensile Strength The maximum stress a material subjected to a stretching load can withstand without tearing. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p2001) Strength, Tensile,Strengths, Tensile,Tensile Strengths
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D014945 Wound Healing Restoration of integrity to traumatized tissue. Healing, Wound,Healings, Wound,Wound Healings
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

M G Greaney, and R Van Noort, and A Smythe, and T T Irvin
September 1981, Journal de chirurgie,
M G Greaney, and R Van Noort, and A Smythe, and T T Irvin
April 1990, The British journal of surgery,
M G Greaney, and R Van Noort, and A Smythe, and T T Irvin
April 1984, The British journal of surgery,
M G Greaney, and R Van Noort, and A Smythe, and T T Irvin
April 2017, Eklem hastaliklari ve cerrahisi = Joint diseases & related surgery,
M G Greaney, and R Van Noort, and A Smythe, and T T Irvin
August 2015, Scientific reports,
M G Greaney, and R Van Noort, and A Smythe, and T T Irvin
December 1995, Nursing standard (Royal College of Nursing (Great Britain) : 1987),
M G Greaney, and R Van Noort, and A Smythe, and T T Irvin
May 2005, Journal of wound care,
M G Greaney, and R Van Noort, and A Smythe, and T T Irvin
January 2013, Polimery w medycynie,
M G Greaney, and R Van Noort, and A Smythe, and T T Irvin
March 1983, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M G Greaney, and R Van Noort, and A Smythe, and T T Irvin
January 1989, Diabetes care,
Copied contents to your clipboard!