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Patients with hypogammaglobulinaemia commonly receive regular long-term replacement therapy with a concentrate of pooled normal human immunoglobulin G (IgG) containing an organic mercury compound (thiomersal) as a preservative. In 26 such patients the total estimated mercury dosage received ranged from 4 to 734 mg (mean 157 mg) over treatment periods of six months to 17 years (mean 6.5 years). Nineteen patients (73%) had raised urine mercury concentrations, but no correlation was found between urine mercury and the age of the patient, the IgG dose, or the duration of treatment. Urine mercury concentrations are often used to control exposure and evaluate risks in exposed subjects. Hence most patients with hypogammaglobulinaemia are theoretically at risk from mercury exposure, although no clinical evidence of toxicity is yet apparent.
M R Haeney, and
G F Carter, and
W B Yeoman, and
R A Thompson
January 1971,
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M R Haeney, and
G F Carter, and
W B Yeoman, and
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November 1982,
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M R Haeney, and
G F Carter, and
W B Yeoman, and
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May 1983,
Dental economics - oral hygiene,
M R Haeney, and
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February 1984,
Scandinavian journal of work, environment & health,
M R Haeney, and
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M R Haeney, and
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January 1991,
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M R Haeney, and
G F Carter, and
W B Yeoman, and
R A Thompson
June 1985,
Postgraduate medical journal,
M R Haeney, and
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R A Thompson
March 1977,
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M R Haeney, and
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W B Yeoman, and
R A Thompson
September 2010,
Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists),
M R Haeney, and
G F Carter, and
W B Yeoman, and
R A Thompson
March 2007,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
