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The rat, an animal without testosterone-estrogen-binding-globulin, was treated with L-T4 to the point of hyperthyroidism in order to study the hypothalamic-pituitary-testicular axis during this condition. Hyperthyroidism led to a significant decline in serum FSH, a fall in serum LH which was not satistically significant, and no change in serum levels of testosterone or estradiol. Testes of hyperthyroid rats produced significantly more testosterone during in vitro incubations than did the testes of control animals. We conclude that hyperthyroidism in the rat leads to a fall in FSH levels either via direct pituitary suppression or via accelerated FSH metabolism. In addition, in vitro studies suggest that excess thyroid hormone may stimulate intratesticular 17 beta-hydroxysteroid dehydrogenase.
G Schneider, and
K Kopach, and
H Ohanian, and
V Bonnefond, and
J C Mittler, and
N H Ertel
January 2000,
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association,
G Schneider, and
K Kopach, and
H Ohanian, and
V Bonnefond, and
J C Mittler, and
N H Ertel
April 1991,
Molecular and cellular endocrinology,
G Schneider, and
K Kopach, and
H Ohanian, and
V Bonnefond, and
J C Mittler, and
N H Ertel
January 2013,
Current medicinal chemistry,
G Schneider, and
K Kopach, and
H Ohanian, and
V Bonnefond, and
J C Mittler, and
N H Ertel
March 2002,
Endocrinology and metabolism clinics of North America,
G Schneider, and
K Kopach, and
H Ohanian, and
V Bonnefond, and
J C Mittler, and
N H Ertel
June 1998,
The Psychiatric clinics of North America,
G Schneider, and
K Kopach, and
H Ohanian, and
V Bonnefond, and
J C Mittler, and
N H Ertel
December 1984,
Danish medical bulletin,
G Schneider, and
K Kopach, and
H Ohanian, and
V Bonnefond, and
J C Mittler, and
N H Ertel
February 2013,
Age (Dordrecht, Netherlands),
G Schneider, and
K Kopach, and
H Ohanian, and
V Bonnefond, and
J C Mittler, and
N H Ertel
August 1975,
The Journal of endocrinology,
G Schneider, and
K Kopach, and
H Ohanian, and
V Bonnefond, and
J C Mittler, and
N H Ertel
April 1992,
International journal of immunopharmacology,
G Schneider, and
K Kopach, and
H Ohanian, and
V Bonnefond, and
J C Mittler, and
N H Ertel
August 2008,
American journal of physiology. Endocrinology and metabolism,
