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Serum somatomedin activity (SM-act) and cartilage metabolism were compared in acutely fasted, marasmic (M), and marasmic kwashiorkor (MK) rats. SM-act was estimated in the porcine bioassay. In vitro uptake of [35S]sulfate and [3H]methylthymidine in costal cartilage of the experimental animals during an incubation in medium immediately after sacrifice, called endogenous activity, and the effect of incubation in 20% normal human plasma after a preincubation of 22 h in medium only, called plasma responsiveness", were determined. Acutely fasted rats had lowered SM-act and a circulating heat-labile inhibitor. Endogenous activity and responsiveness of cartilage were depressed. MK rats (fed ad libitum a 0.5% casein, isocaloric food) showed a profound depression of growth and cartilage endogenous activity despite only partially reduced SM-act and increased responsiveness. M rats received normal food and were pair-fed with MK rats, consuming approximately 0.08 g/g BW . day. They showed very depressed SM-act and low endogenous activity, and responsiveness was increased, though less than in the MK rats. On refeeding M rats, SM-act and cartilage responsiveness increased, followed by an increase of endogenous activity. Catch-up growth was best related to [3H]methylthymidine incorporation by cartilage (endogenous activity). In conclusion, these two types of experimental chronic malnutrition induce a more diversified pattern than does acute fasting. During malnutrition, cartilage metabolism does not reflect bioassayable SM-act of serum but rather the other effects of the nutritional insult. On refeeding, the expected relationship of SM-act and cartilage metabolism is rapidly restored.
D A Price, and
J M Wit, and
S van Buul-Offers, and
A M Korteland-van Male, and
A K van Rooyen-Wehmeijer, and
C Hoogerbrugge, and
J L Van den Brande
March 1988,
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D A Price, and
J M Wit, and
S van Buul-Offers, and
A M Korteland-van Male, and
A K van Rooyen-Wehmeijer, and
C Hoogerbrugge, and
J L Van den Brande
April 1984,
Bioscience reports,
D A Price, and
J M Wit, and
S van Buul-Offers, and
A M Korteland-van Male, and
A K van Rooyen-Wehmeijer, and
C Hoogerbrugge, and
J L Van den Brande
July 1967,
The American journal of physiology,
D A Price, and
J M Wit, and
S van Buul-Offers, and
A M Korteland-van Male, and
A K van Rooyen-Wehmeijer, and
C Hoogerbrugge, and
J L Van den Brande
June 1976,
Diabetes,
D A Price, and
J M Wit, and
S van Buul-Offers, and
A M Korteland-van Male, and
A K van Rooyen-Wehmeijer, and
C Hoogerbrugge, and
J L Van den Brande
November 1971,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
D A Price, and
J M Wit, and
S van Buul-Offers, and
A M Korteland-van Male, and
A K van Rooyen-Wehmeijer, and
C Hoogerbrugge, and
J L Van den Brande
June 1966,
Nutrition reviews,
D A Price, and
J M Wit, and
S van Buul-Offers, and
A M Korteland-van Male, and
A K van Rooyen-Wehmeijer, and
C Hoogerbrugge, and
J L Van den Brande
April 1974,
European journal of biochemistry,
D A Price, and
J M Wit, and
S van Buul-Offers, and
A M Korteland-van Male, and
A K van Rooyen-Wehmeijer, and
C Hoogerbrugge, and
J L Van den Brande
July 1976,
Endocrinology,
D A Price, and
J M Wit, and
S van Buul-Offers, and
A M Korteland-van Male, and
A K van Rooyen-Wehmeijer, and
C Hoogerbrugge, and
J L Van den Brande
May 1983,
The Journal of endocrinology,
D A Price, and
J M Wit, and
S van Buul-Offers, and
A M Korteland-van Male, and
A K van Rooyen-Wehmeijer, and
C Hoogerbrugge, and
J L Van den Brande
October 1964,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
