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The biological activity of 1(OH) vitamin D3 was evaluated in 2 cases of vitamin D dependency. For the improvement of serum chemistry and increment of urinary excretion of calcium 1(OH) vitamin D3 was 500--1000 times more active than vitamin D2. The administration of 0.05 microg/kg/day and 0.1 microg/kg/day of 1(OH) vitamin D3 were equally effective to keep the serum chemistry within normal limits. However, urinary excretion of calcium increased to an abnormal height on 0.1 microg/kg/day of 1(OH) vitamin D3. On the other hand, administration of 0.05 microg/kg/day of 1(OH) vitamin D3 kept both serum level and urinary excretion of calcium normal. It is suggested that 0.05 microg/kg/day is close to the optimum requirement of 1(OH) vitamin D3 in vitamin D dependency and this should correspond to the essential requirement of 1(OH) vitamin D3 in man.
Y Tsuchiya, and
N Matsuo, and
H Cho, and
K Tsubouchi, and
M Kumagai
January 1984,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
Y Tsuchiya, and
N Matsuo, and
H Cho, and
K Tsubouchi, and
M Kumagai
March 1979,
British medical journal,
Y Tsuchiya, and
N Matsuo, and
H Cho, and
K Tsubouchi, and
M Kumagai
June 2004,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
Y Tsuchiya, and
N Matsuo, and
H Cho, and
K Tsubouchi, and
M Kumagai
February 1990,
Journal of medicinal chemistry,
Y Tsuchiya, and
N Matsuo, and
H Cho, and
K Tsubouchi, and
M Kumagai
April 1989,
Indian pediatrics,
Y Tsuchiya, and
N Matsuo, and
H Cho, and
K Tsubouchi, and
M Kumagai
June 1976,
The Journal of clinical investigation,
Y Tsuchiya, and
N Matsuo, and
H Cho, and
K Tsubouchi, and
M Kumagai
January 1980,
Archives of disease in childhood,
Y Tsuchiya, and
N Matsuo, and
H Cho, and
K Tsubouchi, and
M Kumagai
August 1977,
FEBS letters,
Y Tsuchiya, and
N Matsuo, and
H Cho, and
K Tsubouchi, and
M Kumagai
November 1985,
Chemical & pharmaceutical bulletin,
Y Tsuchiya, and
N Matsuo, and
H Cho, and
K Tsubouchi, and
M Kumagai
March 1992,
Steroids,
