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A model of experimental renal osteodystrophy was established in the rats with chronic renal failure induced by partial nephrectomy and therapeutic effects of 1 alpha-hydroxyvitamin D3 (1 alpha-OH-D3) were studied. Male Wistar rats weighing 180 g were 5/6 nephrectomized and fed a normal diet (Ca and P : 1%) for 6 months. After the surgery, serum creatinine levels increased 60% and thereafter continued to rise gradually with their growth for 4 to 5 months, followed by rapid increase. The serum phosphorus levels were also elevated concomitantly and the serum calcium concentrations were normal. Marked bone resorption accompanied with hypertrophy of parathyroid glands was observed by histological examinations (Tetrachrome-Fuchsin stain, contact microradiography and H-E stain). The bone resorption seemed to be due to secondary hyperparathyroidism. Treatment with 0.25 micrograms/kg/day p.o. of 1 alpha-OH-D3 for 10 days in the uremic state resulted in remarkable new bone formation which was confirmed by histological examinations. These results clearly demonstrated that the reduction of nephron mass play a critical clue of renal osteodystrophy and 1 alpha-OH-D3 appears to have a good potential for clinical use in patients with renal failure and metabolic bone diseases.
Y Kawaguchi, and
H Kawashima, and
K Ueno, and
Y Izawa, and
T Makita, and
S Kurozumi, and
Y Hashimoto, and
M Yamamoto, and
Y Kimura, and
N Imamura, and
Y Oda, and
S Sakai, and
Y Ogura, and
K Kushida, and
T Inoue
December 1978,
Endocrinologia japonica,
Y Kawaguchi, and
H Kawashima, and
K Ueno, and
Y Izawa, and
T Makita, and
S Kurozumi, and
Y Hashimoto, and
M Yamamoto, and
Y Kimura, and
N Imamura, and
Y Oda, and
S Sakai, and
Y Ogura, and
K Kushida, and
T Inoue
May 1977,
The Journal of pediatrics,
Y Kawaguchi, and
H Kawashima, and
K Ueno, and
Y Izawa, and
T Makita, and
S Kurozumi, and
Y Hashimoto, and
M Yamamoto, and
Y Kimura, and
N Imamura, and
Y Oda, and
S Sakai, and
Y Ogura, and
K Kushida, and
T Inoue
October 1982,
Nihon Jinzo Gakkai shi,
Y Kawaguchi, and
H Kawashima, and
K Ueno, and
Y Izawa, and
T Makita, and
S Kurozumi, and
Y Hashimoto, and
M Yamamoto, and
Y Kimura, and
N Imamura, and
Y Oda, and
S Sakai, and
Y Ogura, and
K Kushida, and
T Inoue
December 1982,
The Tohoku journal of experimental medicine,
Y Kawaguchi, and
H Kawashima, and
K Ueno, and
Y Izawa, and
T Makita, and
S Kurozumi, and
Y Hashimoto, and
M Yamamoto, and
Y Kimura, and
N Imamura, and
Y Oda, and
S Sakai, and
Y Ogura, and
K Kushida, and
T Inoue
January 1981,
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
Y Kawaguchi, and
H Kawashima, and
K Ueno, and
Y Izawa, and
T Makita, and
S Kurozumi, and
Y Hashimoto, and
M Yamamoto, and
Y Kimura, and
N Imamura, and
Y Oda, and
S Sakai, and
Y Ogura, and
K Kushida, and
T Inoue
October 1980,
Japanese journal of pharmacology,
Y Kawaguchi, and
H Kawashima, and
K Ueno, and
Y Izawa, and
T Makita, and
S Kurozumi, and
Y Hashimoto, and
M Yamamoto, and
Y Kimura, and
N Imamura, and
Y Oda, and
S Sakai, and
Y Ogura, and
K Kushida, and
T Inoue
January 1980,
Minerva nefrologica,
Y Kawaguchi, and
H Kawashima, and
K Ueno, and
Y Izawa, and
T Makita, and
S Kurozumi, and
Y Hashimoto, and
M Yamamoto, and
Y Kimura, and
N Imamura, and
Y Oda, and
S Sakai, and
Y Ogura, and
K Kushida, and
T Inoue
June 1978,
The New England journal of medicine,
Y Kawaguchi, and
H Kawashima, and
K Ueno, and
Y Izawa, and
T Makita, and
S Kurozumi, and
Y Hashimoto, and
M Yamamoto, and
Y Kimura, and
N Imamura, and
Y Oda, and
S Sakai, and
Y Ogura, and
K Kushida, and
T Inoue
October 1981,
Acta orthopaedica Scandinavica,
Y Kawaguchi, and
H Kawashima, and
K Ueno, and
Y Izawa, and
T Makita, and
S Kurozumi, and
Y Hashimoto, and
M Yamamoto, and
Y Kimura, and
N Imamura, and
Y Oda, and
S Sakai, and
Y Ogura, and
K Kushida, and
T Inoue
April 1979,
Calcified tissue international,
