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Ethynyloestradiol was administered to rabbits, guinea pigs and rats, and the concentration of the steroid in blood was measured by radioimmunoassay. In both rabbits and guinea pigs, levels of conjugated steroid were much higher than those of the freely extractable form. Whereas considerable amounts of steroid were present in a congugated form in plasma 24 h after injection, none was present at this time in a freely extractable form. There were significant differences between young and adult rabbits and guinea pigs in the rate at which ethynyloestradiol was metabolized. The amounts present in the freely extractable form in rats were higher than in the other two species but no steroid was detected in the conjugated fraction. The results are compared with previous findings in humans.
M A Ghatei, and
K Fotherby
February 1975,
Journal of steroid biochemistry,
M A Ghatei, and
K Fotherby
January 1978,
Drug metabolism and disposition: the biological fate of chemicals,
M A Ghatei, and
K Fotherby
December 1992,
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes,
M A Ghatei, and
K Fotherby
April 1960,
Comptes rendus hebdomadaires des seances de l'Academie des sciences,
M A Ghatei, and
K Fotherby
September 1969,
Food and cosmetics toxicology,
M A Ghatei, and
K Fotherby
December 1977,
Archives internationales de pharmacodynamie et de therapie,
M A Ghatei, and
K Fotherby
February 1965,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M A Ghatei, and
K Fotherby
September 1973,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M A Ghatei, and
K Fotherby
August 1960,
Journal of neurochemistry,
M A Ghatei, and
K Fotherby
March 1975,
Xenobiotica; the fate of foreign compounds in biological systems,
