Biomaterial Database

Tissue distribution of inhaled mercury vapor in acatalasemic mice. 1979

Y Sugata, and S Halbach, and J Allen, and T W Clarkson

Substantial differences were observed in the pattern of tissue deposition in normal versus acatalasemic mice after inhalation of radioactive mercury vapor. Liver deposition was approximately double and lung deposition approximately one-half the corresponding deposition in normal animals. These results lend further support to the idea that the hydrogen-peroxide catalase peroxidative pathway plays a role in the metabolism of inhaled mercury vapor.

UI	MeSH Term	Description	Entries
D008628	Mercury	A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
D002374	Catalase	An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.	Catalase A,Catalase T,Manganese Catalase,Mn Catalase
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014018	Tissue Distribution	Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.	Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D020642	Acatalasia	A rare autosomal recessive disorder resulting from the absence of CATALASE activity. Though usually asymptomatic, a syndrome of oral ulcerations and gangrene may be present.	Acatalasemia,Hypocatalasemia,Acatalasemia Japanese Type,Acatalasemia Swiss Type,Catalase Deficiency,Hypocatalasia,Takahara Disease,Takahara's Disease,Catalase Deficiencies,Deficiencies, Catalase,Deficiency, Catalase,Disease, Takahara,Disease, Takahara's,Japanese Type, Acatalasemia,Swiss Type, Acatalasemia,Takaharas Disease