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Cerebral blood flow was studied by the arteriovenous oxygen difference method in patients with severe hypertension and in normotensive controls. The blood pressure was lowered to study the lower limit of autoregulation (the pressure below which cerebral blood flow decreases) and the pressure limit of brain hypoxia. Both limits were shifted upwards in the hypertensive patients, probably as a consequence of hypertrophy of the arteriolar walls. These findings have practical implications for antihypertensive therapy.When the blood pressure was raised some patients showed an upper limit of autoregulation beyond which an increase of cerebral blood flow above the resting value was seen without clinical symptoms. No evidence of vasospasm was found in any patient at high blood pressure. These observations may be of importance for the understanding of the pathogenesis of hypertensive encephalopathy.
S Strandgaard, and
J Olesen, and
E Skinhoj, and
N A Lassen
January 1978,
Acta neurologica Scandinavica. Supplementum,
S Strandgaard, and
J Olesen, and
E Skinhoj, and
N A Lassen
February 1967,
Journal of the Medical Association of Georgia,
S Strandgaard, and
J Olesen, and
E Skinhoj, and
N A Lassen
February 1992,
Hypertension (Dallas, Tex. : 1979),
S Strandgaard, and
J Olesen, and
E Skinhoj, and
N A Lassen
January 1991,
Journal of cardiovascular pharmacology,
S Strandgaard, and
J Olesen, and
E Skinhoj, and
N A Lassen
July 1943,
British medical journal,
S Strandgaard, and
J Olesen, and
E Skinhoj, and
N A Lassen
January 1976,
Progress in cardiovascular diseases,
S Strandgaard, and
J Olesen, and
E Skinhoj, and
N A Lassen
January 1954,
Documenta ophthalmologica. Advances in ophthalmology,
S Strandgaard, and
J Olesen, and
E Skinhoj, and
N A Lassen
March 1958,
Montpellier medical,
S Strandgaard, and
J Olesen, and
E Skinhoj, and
N A Lassen
August 1988,
Hypertension (Dallas, Tex. : 1979),
S Strandgaard, and
J Olesen, and
E Skinhoj, and
N A Lassen
July 1943,
British medical journal,
