Biomaterial Database

Evidence for primary afferent depolarization of single tooth-pulp afferents in the cat. 1979

S J Lisney

1. Responses of single tooth-pulp afferents to electrical stimulation of sites in the trigeminal sensory nuclear complex were recorded from caine teeth in cats. 2. Changes in the excitability of the central terminals of a pulpal afferent after stimulation of other groups of sensory nerves were taken as evidence for changes in their polarization. 3. Electrical stimulation of nerves in other teeth resulted in raised excitability of the central terminals of pulpal afferents lasting up to 300 msec. The greatest effects were observed 30--100 msec after the conditioning stimulus. 4. Increased terminal excitability was also observed after the ipsilateral infraorbital nerve was stimulated. This occurred when only nerve fibres with conduction velocities in the A alpha range were excited. 5. Mechanical stimulation of a canine tooth produced increases in terminal excitability of pulpal afferents innervating the same tooth. 6. A similar effect was also observed after a brief pull on a group of ipsilateral mystacial vibrissae. 7. No evidence of decreases in the excitability of the central terminals of tooth-pulp afferents was obtained with any of the conditioning stimuli.

UI	MeSH Term	Description	Entries
D009475	Neurons, Afferent	Neurons which conduct NERVE IMPULSES to the CENTRAL NERVOUS SYSTEM.	Afferent Neurons,Afferent Neuron,Neuron, Afferent
D010812	Physical Stimulation	Act of eliciting a response from a person or organism through physical contact.	Stimulation, Physical,Physical Stimulations,Stimulations, Physical
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D003481	Cuspid	The third tooth to the left and to the right of the midline of either jaw, situated between the second INCISOR and the premolar teeth (BICUSPID). (Jablonski, Dictionary of Dentistry, 1992, p817)	Canine Tooth,Canine Teeth,Cuspids,Teeth, Canine,Tooth, Canine
D003782	Dental Pulp	A richly vascularized and innervated connective tissue of mesodermal origin, contained in the central cavity of a tooth and delimited by the dentin, and having formative, nutritive, sensory, and protective functions. (Jablonski, Dictionary of Dentistry, 1992)	Dental Pulps,Pulp, Dental,Pulps, Dental
D004558	Electric Stimulation	Use of electric potential or currents to elicit biological responses.	Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D000200	Action Potentials	Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.	Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia