Biomaterial Database

The influence of body temperature on the ventilatory response to CO 2 in anaesthetized rats. 1973

F Palecek, and M Chválová, and J Novenko

The breathing frequency, tidal volume and partial pressure of CO2 in arterial blood (PaCO2) were measured continuously in urethan anaesthetized rats at different body temperatures. In urethan anaesthesia the colonic temperature of our rats averaged 33.5 plus or minus 1.29 degree Celsius, when the ambient temperature was 22-24 degree Celsius. At this temperature their PaCO2 was the highest, 42 plus or minus 1.2 mm Hg on the average. With decreasing or increasing body temperature the PaCO2 declined. The breathing frequency increased with increasing body temperature. The ventilatory CO2 response curve in warmed rats was shifted towards higher ventilation. Its relative slope was parallel, in absolute units it was steeper than that of the cooled animals. After vagotomy the rate of breathing averaged 42-48 percent of the control values, at all body temperatures. The calculated inspirio-inhibitory index (V/VT) shows a relatively identical decrease (37-39 percent) after vagotomy in warmed, same as in cooled rats. The results indicate that in urethan anaesthetized rats the sensitivity to CO2 remains the same in the range of body temperatures from 28 to 38 degree Celsius. Also the relative role of the vagus nerves does not change within the range of these temperatures.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010313	Partial Pressure	The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Partial Pressures,Pressure, Partial,Pressures, Partial
D012119	Respiration	The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (	Breathing
D012123	Pulmonary Ventilation	The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.	Respiratory Airflow,Ventilation Tests,Ventilation, Pulmonary,Expiratory Airflow,Airflow, Expiratory,Airflow, Respiratory,Test, Ventilation,Tests, Ventilation,Ventilation Test
D001831	Body Temperature	The measure of the level of heat of a human or animal.	Organ Temperature,Body Temperatures,Organ Temperatures,Temperature, Body,Temperature, Organ,Temperatures, Body,Temperatures, Organ
D002245	Carbon Dioxide	A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.	Carbonic Anhydride,Anhydride, Carbonic,Dioxide, Carbon
D000758	Anesthesia	A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014520	Urethane	Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.	Ethyl Carbamate,Urethan,Carbamate, Ethyl
D014628	Vagotomy	The interruption or removal of any part of the vagus (10th cranial) nerve. Vagotomy may be performed for research or for therapeutic purposes.	Vagotomies