-transparent.png){kind=logo}
A new continuous cell line, GOTO, has been established in tissue culture from a human neuroblastoma arising from the adrenal and maintained for 5 years. The cells are small and fibroblast-like, and grow in dense layer. Population doubling time was approximately 48 hr. The modal chromosome number was near-diploid. Neither marker chromosomes nor double-minute chromosomes were abserved. Inoculum of 10(7) cells produced tumors in ATS-treated hamsters and athymic nude mice, and the histological appearance of tumors was consistent with undifferentiated neuroblastoma. Neural features of the cells were also confirmed by ultrastructural examination. Biochemical analysis showed this cell line to be cholinergic. Morphological differentiation leading to neurite formation was induced by cultivation in serum-free medium.
M Sekiguchi, and
T Oota, and
K Sakakibara, and
N Inui, and
G Fujii
June 1989,
Human cell,
M Sekiguchi, and
T Oota, and
K Sakakibara, and
N Inui, and
G Fujii
April 1989,
International journal of cancer,
M Sekiguchi, and
T Oota, and
K Sakakibara, and
N Inui, and
G Fujii
December 1989,
Human cell,
M Sekiguchi, and
T Oota, and
K Sakakibara, and
N Inui, and
G Fujii
January 1999,
Anticancer research,
M Sekiguchi, and
T Oota, and
K Sakakibara, and
N Inui, and
G Fujii
August 2007,
Tissue & cell,
M Sekiguchi, and
T Oota, and
K Sakakibara, and
N Inui, and
G Fujii
September 1993,
Human cell,
M Sekiguchi, and
T Oota, and
K Sakakibara, and
N Inui, and
G Fujii
September 1976,
Cancer research,
M Sekiguchi, and
T Oota, and
K Sakakibara, and
N Inui, and
G Fujii
January 1984,
Anticancer research,
M Sekiguchi, and
T Oota, and
K Sakakibara, and
N Inui, and
G Fujii
September 1983,
Cancer research,
M Sekiguchi, and
T Oota, and
K Sakakibara, and
N Inui, and
G Fujii
December 1989,
Cancer research,
