-transparent.png){kind=logo}
In seven patients with uncomplicated essential hypertension the effects of an acute alpha-adrenergic blockade, alone and combined with a chronic beta-adrenergic blockade, on blood pressure, renal function as measured by standard clearance methods, plasma renin activity, and plasma aldosterone were evaluated. Acute alpha-adrenergic blockade with phentolamine (20 mg by intravenous infusion) significantly enhanced the antihypertensive effect of chronic beta-adrenergic blockade with slow-oxprenolol (160 mg/ day X 14 days) (- 14.5% verus - 7.4% for pulse pressure, - 12.4% versus - 6.0% for diastolic pressure, 2 alpha less than 0.05). Under combined adrenergic blockade renal plasma flow increased, glomerular filtration rate and filtration fraction decreased (2 alpha less than 0.05 each), whereas the fractional clearances of sodium, potassium, free water, and solute load remained unchanged. The activation of the renin-angiotensin-axis, elicited by alpha-adrenergic blockade alone, was suppressed by the preceding beta-adrenergic blockade. These findings demonstrate a favourable antihypertensive action of a combined blockade of alpha- und beta-adrenergic receptor sites without untoward side effects on renal function or the renin-angiotensin-axis.
U Grüninger, and
R Akert, and
H Hunkeler, and
E Wegmüller, and
P Weidmann, and
J Hodler
February 1987,
Journal of clinical pharmacology,
U Grüninger, and
R Akert, and
H Hunkeler, and
E Wegmüller, and
P Weidmann, and
J Hodler
December 1976,
Clinical science and molecular medicine. Supplement,
U Grüninger, and
R Akert, and
H Hunkeler, and
E Wegmüller, and
P Weidmann, and
J Hodler
October 1975,
Klinische Wochenschrift,
U Grüninger, and
R Akert, and
H Hunkeler, and
E Wegmüller, and
P Weidmann, and
J Hodler
January 1976,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
U Grüninger, and
R Akert, and
H Hunkeler, and
E Wegmüller, and
P Weidmann, and
J Hodler
August 1976,
Clinical pharmacology and therapeutics,
U Grüninger, and
R Akert, and
H Hunkeler, and
E Wegmüller, and
P Weidmann, and
J Hodler
January 1982,
Journal of cardiovascular pharmacology,
U Grüninger, and
R Akert, and
H Hunkeler, and
E Wegmüller, and
P Weidmann, and
J Hodler
October 1976,
Circulation research,
U Grüninger, and
R Akert, and
H Hunkeler, and
E Wegmüller, and
P Weidmann, and
J Hodler
January 1975,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
U Grüninger, and
R Akert, and
H Hunkeler, and
E Wegmüller, and
P Weidmann, and
J Hodler
October 1982,
European journal of clinical pharmacology,
U Grüninger, and
R Akert, and
H Hunkeler, and
E Wegmüller, and
P Weidmann, and
J Hodler
June 1975,
Circulation research,
