Biomaterial Database

[The influence of age and weight on the normal oral glucose tolerance (author's transl)]. 1979

W Schimmler, and D Ullrich, and M Kurz

The individual influence of age and weight on the normal glucose tolerance after an oral glucose load of 50 g was investigated in 332 test subjects (231 male + 101 female) presenting a healthy metabolism. The results show that, even within the range of normal glucose tolerance, the relative weight (age factor eliminated) exerts an influence both on the fasting blood sugar and on the 1 h-value (p less than or equal to 0.01), in women even on the 2 h-value (p less than or equal to 0.05) ("plain" glucose tolerance--weight correlation). The influence of the age factor (weight eliminated) on the normal glucose tolerance can only be demonstrated in the 1 h-value of men as sole value (p less than or equal to 0.01). Here it even slightly exceeds the influence of the weight factor ("plain" glucose tolerance--age correlation). Apart from this value, however, it can be stated that, within the normal glucose tolerance of both male and female subjects, the weight factor is of greater importance than the age factor. With increasing weight the sugar levels progressively approach the upper limit of the norm. Perhaps this is already the forefield to future secondary arteriopathies.

UI	MeSH Term	Description	Entries
D007328	Insulin	A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).	Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D008297	Male		Males
D001786	Blood Glucose	Glucose in blood.	Blood Sugar,Glucose, Blood,Sugar, Blood
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D005260	Female		Females
D005951	Glucose Tolerance Test	A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).	Intravenous Glucose Tolerance,Intravenous Glucose Tolerance Test,OGTT,Oral Glucose Tolerance,Oral Glucose Tolerance Test,Glucose Tolerance Tests,Glucose Tolerance, Oral
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000078790	Insulin Secretion	Production and release of insulin from PANCREATIC BETA CELLS that primarily occurs in response to elevated BLOOD GLUCOSE levels.	Secretion, Insulin
D000367	Age Factors	Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.	Age Reporting,Age Factor,Factor, Age,Factors, Age
D012306	Risk	The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.	Relative Risk,Relative Risks,Risk, Relative,Risks,Risks, Relative