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Prostaglandin E(2) (PGE(2)) was infused intravenously to eight women for the termination of pregnancy and tests of platelet function: coagulation and fibrinolysis were studied before and during the infusion.Platelet adhesiveness, as measured by a cellophane membrane test-cell system, was significantly diminished by PGE(2), a change which was not noted by the glass-bead column technique. The administration of PGE(2) caused more rapid platelet disaggregation following ADP-induced aggregation but had no effect on the platelet count, collagen-induced aggregation, or platelet factor 3 activity. An increase in plasma antithrombin concentration and euglobulin lysis activity was also noted. These results support the concept that prostaglandin E(2) might have a role in the prevention of thrombosis.
P W Howie, and
A A Calder, and
C D Forbes, and
C R Prentice
January 1986,
Diabetes/metabolism reviews,
P W Howie, and
A A Calder, and
C D Forbes, and
C R Prentice
October 1971,
Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology,
P W Howie, and
A A Calder, and
C D Forbes, and
C R Prentice
January 1976,
Arzneimittel-Forschung,
P W Howie, and
A A Calder, and
C D Forbes, and
C R Prentice
August 1975,
Archives internationales de pharmacodynamie et de therapie,
P W Howie, and
A A Calder, and
C D Forbes, and
C R Prentice
September 1975,
Archives internationales de pharmacodynamie et de therapie,
P W Howie, and
A A Calder, and
C D Forbes, and
C R Prentice
April 1975,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
P W Howie, and
A A Calder, and
C D Forbes, and
C R Prentice
March 1977,
Blut,
P W Howie, and
A A Calder, and
C D Forbes, and
C R Prentice
August 2005,
Thrombosis and haemostasis,
P W Howie, and
A A Calder, and
C D Forbes, and
C R Prentice
October 1972,
Gut,
P W Howie, and
A A Calder, and
C D Forbes, and
C R Prentice
January 1967,
Acta chirurgica Scandinavica. Supplementum,
