Biomaterial Database

Rheologic properties of erythrocytes in Duchenne muscular dystrophy. 1979

W Tillmann, and H G Lenard, and D Wagner, and H Dönges, and W Schröter

The transformation of erythrocytes into echinocytes by suspension in isotonic phosphate buffer was increased in patients with Duchenne muscular dystrophy (DMD) as compared to healthy controls. The transformation was enhanced when glass slides instead of polystyrole slides were used for observation. Viscosity of erythrocyte suspensions with a hematocrit of 80% was the same in patients and controls. The mean flow rate of erythrocyte suspensions in autologous plasma was only slightly reduced in the patient group, but decreased markedly after suspension of the cells in phosphate buffer, without as well as after preincubation with 10 mM Na salicylate. The decreased flow rate in patients is probably due to the increased number of echinocytes and not to an increased membrane rigidity, because the membrane flexibility of isolated ghosts, measured in a viscosimeter, was normal at all shear rates. Echinocyte formation in patients with DMD is strongly dependent on the techniques applied and difficult to evaluate quantitatively by phase contrast microscopy. Filtration of erythrocyte suspensions seems to be a more reliable, quantitative test for increased erythrocyte vulnerability.

UI	MeSH Term	Description	Entries
D009136	Muscular Dystrophies	A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.	Muscular Dystrophy,Myodystrophica,Myodystrophy,Dystrophies, Muscular,Dystrophy, Muscular,Myodystrophicas,Myodystrophies
D001809	Blood Viscosity	The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.	Blood Viscosities,Viscosities, Blood,Viscosity, Blood
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D004910	Erythrocyte Membrane	The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.	Erythrocyte Ghost,Red Cell Cytoskeleton,Red Cell Ghost,Erythrocyte Cytoskeleton,Cytoskeleton, Erythrocyte,Cytoskeleton, Red Cell,Erythrocyte Cytoskeletons,Erythrocyte Ghosts,Erythrocyte Membranes,Ghost, Erythrocyte,Ghost, Red Cell,Membrane, Erythrocyte,Red Cell Cytoskeletons,Red Cell Ghosts
D004911	Erythrocyte Volume	Volume of circulating ERYTHROCYTES . It is usually measured by RADIOISOTOPE DILUTION TECHNIQUE.	Red Cell Mass,Erythrocyte Volumes,Mass, Red Cell,Masses, Red Cell,Red Cell Masses,Volume, Erythrocyte,Volumes, Erythrocyte
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D012212	Rheology	The study of the deformation and flow of matter, usually liquids or fluids, and of the plastic flow of solids. The concept covers consistency, dilatancy, liquefaction, resistance to flow, shearing, thixotrophy, and VISCOSITY.	Flowmetry,Velocimetry,Velocimetries