[Long-term treatment of tuberculosis with isoprodian (author's transl)]. 1979

O Bergsmann, and E Spielmann

The results of combination therapy of Isoprodian with ethambul in patients with severe pulmonary tuberculosis were found to be comparable with the results previously obtained by us with other first-choice therapeutic regimens. 61% of the 140 cavities found before treatment disappeared within 5 months and 74% within 8 months of therapy. Disappearance of bacilli from the sputum was demonstrated in 89% of the patients by 12 weeks and in all patients by 20 weeks of treatment. The satisfactory therapeutic results, the low toxicity, the convenience of administration and, moreover, the economic aspect of the relatively lower cost of Isoprodian therapy justify the further use of Isoprodian supplemented with a first-choice tuberculostatic drug in the initial phase of treatment followed by long-term therapy with Isoprodian on its own in the stabilizing phase of even severe cases of tuberculosis.

UI MeSH Term Description Entries
D007538 Isoniazid Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. Isonicotinic Acid Hydrazide,Ftivazide,Isonex,Isonicotinic Acid Vanillylidenehydrazide,Phthivazid,Phthivazide,Tubazide,Acid Vanillylidenehydrazide, Isonicotinic,Hydrazide, Isonicotinic Acid,Vanillylidenehydrazide, Isonicotinic Acid
D007539 Isonicotinic Acids Heterocyclic acids that are derivatives of 4-pyridinecarboxylic acid (isonicotinic acid). Isonicotinic Acid,Acid, Isonicotinic,Acids, Isonicotinic
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011515 Prothionamide Antitubercular agent similar in action and side effects to ETHIONAMIDE. It is used mostly in combination with other agents. Ektebin,Peteha,Protionamide
D003622 Dapsone A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8) Diaminodiphenylsulfone,Sulfonyldianiline,4,4'-Diaminophenyl Sulfone,Avlosulfone,DADPS,Dapsoderm-X,Dapson-Fatol,Diaphenylsulfone,Disulone,Sulfona,4,4' Diaminophenyl Sulfone,Sulfone, 4,4'-Diaminophenyl
D004338 Drug Combinations Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture. Drug Combination,Combination, Drug,Combinations, Drug
D004341 Drug Evaluation Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals. Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D004352 Drug Resistance, Microbial The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS). Antibiotic Resistance,Antibiotic Resistance, Microbial,Antimicrobial Resistance, Drug,Antimicrobial Drug Resistance,Antimicrobial Drug Resistances,Antimicrobial Resistances, Drug,Drug Antimicrobial Resistance,Drug Antimicrobial Resistances,Drug Resistances, Microbial,Resistance, Antibiotic,Resistance, Drug Antimicrobial,Resistances, Drug Antimicrobial
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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