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Substituted anilides of 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole-3-acetic acid. 1973

G Linari, and R Spanò

UI MeSH Term Description Entries
D007213 Indomethacin A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES. Amuno,Indocid,Indocin,Indomet 140,Indometacin,Indomethacin Hydrochloride,Metindol,Osmosin
D007928 Lethal Dose 50 The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population. LD50,Dose 50, Lethal
D008297 Male Males
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D002621 Chemistry A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
D004487 Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE. Dropsy,Hydrops,Anasarca
D005260 Female Females
D006358 Hot Temperature Presence of warmth or heat or a temperature notably higher than an accustomed norm. Heat,Hot Temperatures,Temperature, Hot,Temperatures, Hot
D000700 Analgesics Compounds capable of relieving pain without the loss of CONSCIOUSNESS. Analgesic,Anodynes,Antinociceptive Agents,Analgesic Agents,Analgesic Drugs,Agents, Analgesic,Agents, Antinociceptive,Drugs, Analgesic
D000813 Anilides Any aromatic amide obtained by acylation of aniline.

Related Publications

G Linari, and R Spanò
Examination of polymorphism of 1-(p-chlorobenzoyl)-5-methoxy-2-methylindolyl-3-acetic acid.
January 1977, Acta poloniae pharmaceutica,
G Linari, and R Spanò
[Synthesis of 1-(p-chlorobenzoyl)-2-methyl-5-methoxyindolyl-3-acetic acid 2-,3- and 4-pyridylmethylamides].
January 1976, Acta poloniae pharmaceutica,
G Linari, and R Spanò
ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITIES OF INDOMETHACIN, 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID.
September 1963, The Journal of pharmacology and experimental therapeutics,
G Linari, and R Spanò
Crystal and molecular structure of an antiinflammatory agent, indomethacin, 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid.
February 1972, Journal of the American Chemical Society,
G Linari, and R Spanò
[On the pharmacology of 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole acetic acid, a new antiphlogistic agent].
April 1965, Arzneimittel-Forschung,
G Linari, and R Spanò
[Preliminary observations on the clinical use of the glucosamide of N-p-chlorobenzoyl-2-methyl-5-methoxy-indol-3-acetic acid monohydrate].
January 1972, Reumatismo,
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The therapeutic activity of 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid monohydrate glucosamide in rheumatoid arthritis (double blind trial).
March 1975, Arzneimittel-Forschung,
G Linari, and R Spanò
1-P-CHLOROBENZYL-5-METHYLINDOLE-3-ACETIC ACID. SOME 2-SUBSTITUTED DERIVATIVES.
March 1965, Journal of medicinal chemistry,
G Linari, and R Spanò
Design, synthesis and antiinflammatory activity of a new indomethacin ester. 2-[N-[3-(3-(piperidinomethyl)phenoxy)propyl]carbamoylmethylthio]ethyl 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-indole-3-acetate.
March 1991, Chemical & pharmaceutical bulletin,
G Linari, and R Spanò
The disposition of the anti-inflammatory agent 14C-1-(p-chlorobenzoyl)-2-methyl-5-methoxy-3-indolylacetohydroxamic acid (oxametacine) in the rat.
January 1979, Arzneimittel-Forschung,
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