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The localization of coccidioidal meningitis in the basilar regions, with resultant hydrocephalus and uniformly fatal outcome, has necessitated intrathecal injection of amphotericin B via cisternal puncture or subcutaneous ventricular reservoir for successful therapy. A simpler form of treatment is described here, whereby amphotericin B diluted in 10 percent glucose solution is injected via lumbar puncture, and delivered to the base of the skull by tilting the patient to a head-down position. A simultaneously performed hyperbaric cisternogram with (131)I-serum albumin has demonstrated satisfactory migration of the injected bolus to the occiput. This method of administration resulted in successful suppressive treatment of one patient, including two years of follow-up without serious sequelae or relapse.
K P Glynn, and
N P Alazraki, and
T A Waltz
January 1995,
Archives of internal medicine,
K P Glynn, and
N P Alazraki, and
T A Waltz
February 2017,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
K P Glynn, and
N P Alazraki, and
T A Waltz
October 1986,
Archives of internal medicine,
K P Glynn, and
N P Alazraki, and
T A Waltz
December 2001,
Seminars in respiratory infections,
K P Glynn, and
N P Alazraki, and
T A Waltz
September 1973,
California medicine,
K P Glynn, and
N P Alazraki, and
T A Waltz
June 1961,
California medicine,
K P Glynn, and
N P Alazraki, and
T A Waltz
April 1988,
Archives of internal medicine,
K P Glynn, and
N P Alazraki, and
T A Waltz
June 2019,
Clinical neurology and neurosurgery,
K P Glynn, and
N P Alazraki, and
T A Waltz
June 2018,
Mycopathologia,
K P Glynn, and
N P Alazraki, and
T A Waltz
January 1992,
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology,
