Biomaterial Database

Cap survey results for factor VIII assays (1977-1978). 1979

T A Kocoshis, and D A Triplett

This paper combines the data from the 1976, 1977, and 1978 CAP Surveys concerning factor VIII methods. The different instrument-reagent combinations are ranked according to precision and sensitivity. The results of questionnaires on specific assay technic from 1977 and 1978 are analyzed. The number of laboratories performing factor VIII assays has increased from 1976 to 1978. There was a poor correlation between precision and sensitivity in most systems. For any given system, there was considerable variation in precision from a normal factor VIII level specimen to a low factor VIII specimen. Certain technics, such as the dilutions on normal plasma used to construct the standard activity curve, show considerable interlaboratory variation. The need for standardization of factor VIII assay methods is evident from this study.

UI	MeSH Term	Description	Entries
D007753	Laboratories	Facilities equipped to carry out investigative procedures.	Laboratory
D010336	Pathology	A specialty concerned with the nature and cause of disease as expressed by changes in cellular or tissue structure and function caused by the disease process.	Pathologies
D011786	Quality Control	A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)	Control, Quality,Controls, Quality,Quality Controls
D002624	Chemistry, Clinical	The specialty of ANALYTIC CHEMISTRY applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.	Clinical Chemistry
D005169	Factor VIII	Factor VIII of blood coagulation. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.	Coagulation Factor VIII,Factor VIII Clotting Antigen,Factor VIII Coagulant Antigen,Factor VIII Procoagulant Activity,Thromboplastinogen,Blood Coagulation Factor VIII,F VIII-C,Factor 8,Factor 8 C,Factor Eight,Factor VIIIC,Hyate-C,Hyatt-C,F VIII C,Hyate C,HyateC,Hyatt C,HyattC
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000704	Analysis of Variance	A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.	ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D012955	Societies, Medical	Societies whose membership is limited to physicians.	Medical Societies,Medical Society,Society, Medical
D014481	United States	A country in NORTH AMERICA between CANADA and MEXICO.