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The effect of treatment with the factor that inhibits the release of melanocyte stimulating hormone (MSH) identified as 1-prolyl-1-leucylglycinamide (MIF) on brain catecholamine synthesis was examined in normal and hypophysectomized rats. The tripeptide induced a dose-related increase in striatal dopamine synthesis in slices obtained from treated normal animals but not in hypophysectomized animals. Hypothalamic norepinephrine synthesis was unaltered by MIF treatment in normal as well as in hypophysectomized rats. In addition, dopamine and norepinephrine syntheses were depressed in untreated hypophysectomized animals, as compared to normal controls. These results constitute the first direct demonstration of a central neurochemical effect of a hypothalamic factor.
E Friedman, and
J Friedman, and
S Gershon
February 1969,
Journal of reproduction and fertility,
E Friedman, and
J Friedman, and
S Gershon
March 1975,
Science (New York, N.Y.),
E Friedman, and
J Friedman, and
S Gershon
August 1974,
Nature,
E Friedman, and
J Friedman, and
S Gershon
February 1999,
Molecular endocrinology (Baltimore, Md.),
E Friedman, and
J Friedman, and
S Gershon
November 1971,
The Journal of endocrinology,
E Friedman, and
J Friedman, and
S Gershon
January 1998,
Brain research,
E Friedman, and
J Friedman, and
S Gershon
June 1977,
Pharmacological research communications,
E Friedman, and
J Friedman, and
S Gershon
October 1971,
Journal of neurochemistry,
E Friedman, and
J Friedman, and
S Gershon
June 1996,
Cellular and molecular neurobiology,
E Friedman, and
J Friedman, and
S Gershon
October 1967,
Endocrinology,
