-transparent.png){kind=logo}
The present studies investigated vascular responses to electrical stimulation of the posterior hypothalamus in isolated but perfused and innervated subcutaneous adipose tissue in adult dogs. Three groups of dogs were distinguished: in one, electrical stimulation elicited vasodilation; in another, vasoconstriction, and in a third, neither significant vasodilation nor vasoconstriction occurred. Histological examination revealed that electrode placements were in the medial posterior hypothalamus, the lateral posterior hypothalamus, and the medial septal region, respectively. Hypothalamic stimulation failed to alter concentrations of free fatty acids or glycerol in venous blood from subcutaneous fat. Local beta-adrenergic block (propranolol) reversed the vasodilation to vasoconstriction while local alpha-adrenergic block (dihydroergotamine) abolished the vaso constrictor response. These results suggest that selective stimulation of the posterior hypothalamus results in neurogenic activation of both alpha- and beta-adrenergic mechanisms in adipose tissue vasculature. beta-Adrenergic vasodilation appears to predominate if the electrode is located medially, and alpha-adrenergic vasoconstriction appears to predominate if the electrode is located in the lateral posterior hypothalamus.
R E Parker, and
R E Hall, and
H B Marr, and
N S Skinner
September 1983,
Acta physiologica Scandinavica,
R E Parker, and
R E Hall, and
H B Marr, and
N S Skinner
August 1978,
The Journal of physiology,
R E Parker, and
R E Hall, and
H B Marr, and
N S Skinner
February 1971,
Acta physiologica Scandinavica,
R E Parker, and
R E Hall, and
H B Marr, and
N S Skinner
January 1967,
Acta pharmacologica et toxicologica,
R E Parker, and
R E Hall, and
H B Marr, and
N S Skinner
September 1967,
Acta physiologica Scandinavica,
R E Parker, and
R E Hall, and
H B Marr, and
N S Skinner
January 1976,
Acta physiologica Scandinavica. Supplementum,
R E Parker, and
R E Hall, and
H B Marr, and
N S Skinner
January 1976,
The Japanese journal of physiology,
R E Parker, and
R E Hall, and
H B Marr, and
N S Skinner
December 1970,
Acta physiologica Scandinavica,
R E Parker, and
R E Hall, and
H B Marr, and
N S Skinner
March 1976,
Acta physiologica Scandinavica,
R E Parker, and
R E Hall, and
H B Marr, and
N S Skinner
June 1970,
Acta physiologica Scandinavica,
