BIOMAT Database Logo BIOMAT Database Logo

Synthesis and antiinflammatory activity of 1-alkyl-4-aryl-2(1H)-quinazolinones and quinazolinethiones. 1973

R V Coombs, and R P Danna, and M Denzer, and G E Hardtmann, and B Huegi, and G Koletar, and J Koletar, and H Ott, and E Jukniewicz, and J W Perrine, and E I Takesue, and J H Trapold

UI MeSH Term Description Entries
D007659 Ketones Organic compounds containing a carbonyl group Ketone
D011799 Quinazolines A group of aromatic heterocyclic compounds that contain a bicyclic structure with two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring. Quinazoline
D001920 Bradykinin A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter. Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg,Bradykinin Acetate, (9-D-Arg)-Isomer,Bradykinin Diacetate,Bradykinin Hydrochloride,Bradykinin Triacetate,Bradykinin, (1-D-Arg)-Isomer,Bradykinin, (2-D-Pro)-Isomer,Bradykinin, (2-D-Pro-3-D-Pro-7-D-Pro)-Isomer,Bradykinin, (2-D-Pro-7-D-Pro)-Isomer,Bradykinin, (3-D-Pro)-Isomer,Bradykinin, (3-D-Pro-7-D-Pro)-Isomer,Bradykinin, (5-D-Phe)-Isomer,Bradykinin, (5-D-Phe-8-D-Phe)-Isomer,Bradykinin, (6-D-Ser)-Isomer,Bradykinin, (7-D-Pro)-Isomer,Bradykinin, (8-D-Phe)-Isomer,Bradykinin, (9-D-Arg)-Isomer,Arg Pro Pro Gly Phe Ser Pro Phe Arg
D002351 Carrageenan A water-soluble extractive mixture of sulfated polysaccharides from RED ALGAE. Chief sources are the Irish moss CHONDRUS CRISPUS (Carrageen), and Gigartina stellata. It is used as a stabilizer, for suspending COCOA in chocolate manufacture, and to clarify BEVERAGES. Carrageenin,iota-Carrageenan,kappa-Carrageenan,lambda-Carrageenan,iota Carrageenan,kappa Carrageenan,lambda Carrageenan
D004487 Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE. Dropsy,Hydrops,Anasarca
D005528 Foot The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones. Feet
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D006941 Hyperesthesia Increased sensitivity to cutaneous stimulation due to a diminished threshold or an increased response to stimuli. Hyperesthesia, Tactile,Hyperesthesia, Thermal,Hyperesthetic Sensations,Oxyesthesia,Hyperesthesias,Hyperesthesias, Tactile,Hyperesthesias, Thermal,Hyperesthetic Sensation,Oxyesthesias,Sensation, Hyperesthetic,Sensations, Hyperesthetic,Tactile Hyperesthesia,Tactile Hyperesthesias,Thermal Hyperesthesia,Thermal Hyperesthesias
D000315 Adrenalectomy Excision of one or both adrenal glands. (From Dorland, 28th ed) Adrenalectomies
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

R V Coombs, and R P Danna, and M Denzer, and G E Hardtmann, and B Huegi, and G Koletar, and J Koletar, and H Ott, and E Jukniewicz, and J W Perrine, and E I Takesue, and J H Trapold
SYNTHESIS AND ACTIVITY OF 1-ALKYL-2-ARYL-2,3-DIHYDRO-4(1H)QUINAZOLINONES.
November 1963, Journal of pharmaceutical sciences,
R V Coombs, and R P Danna, and M Denzer, and G E Hardtmann, and B Huegi, and G Koletar, and J Koletar, and H Ott, and E Jukniewicz, and J W Perrine, and E I Takesue, and J H Trapold
Studies on 4(1H)-quinazolinones. 5. Synthesis and antiinflammatory activity of 4(1H)-quinazolinone derivatives.
May 1985, Journal of medicinal chemistry,
R V Coombs, and R P Danna, and M Denzer, and G E Hardtmann, and B Huegi, and G Koletar, and J Koletar, and H Ott, and E Jukniewicz, and J W Perrine, and E I Takesue, and J H Trapold
Synthesis and cardiotonic activity of a series of substituted 4-alkyl-2(1H)-quinazolinones.
August 1987, Journal of medicinal chemistry,
R V Coombs, and R P Danna, and M Denzer, and G E Hardtmann, and B Huegi, and G Koletar, and J Koletar, and H Ott, and E Jukniewicz, and J W Perrine, and E I Takesue, and J H Trapold
Synthesis and antiinflammatory activity of some 1-alkyl-4-phenylpyrido(2,3-d)pyrimidin-2(1H)-ones.
June 1974, Journal of medicinal chemistry,
R V Coombs, and R P Danna, and M Denzer, and G E Hardtmann, and B Huegi, and G Koletar, and J Koletar, and H Ott, and E Jukniewicz, and J W Perrine, and E I Takesue, and J H Trapold
[Quinazolinones. 16. Synthesis and in vitro pharmacology of 2-aryl-1- ([3-(imidazol-4-yl)propyl]-guanidinylalkyl)-2,3-dihydro-4(1H)- quinazolinones].
February 1989, Archiv der Pharmazie,
R V Coombs, and R P Danna, and M Denzer, and G E Hardtmann, and B Huegi, and G Koletar, and J Koletar, and H Ott, and E Jukniewicz, and J W Perrine, and E I Takesue, and J H Trapold
Synthesis and CYP26A1 inhibitory activity of 1-[benzofuran-2-yl-(4-alkyl/aryl-phenyl)-methyl]-1H-triazoles.
June 2006, Bioorganic & medicinal chemistry,
R V Coombs, and R P Danna, and M Denzer, and G E Hardtmann, and B Huegi, and G Koletar, and J Koletar, and H Ott, and E Jukniewicz, and J W Perrine, and E I Takesue, and J H Trapold
[Quinazolinones. 18. Synthesis and H1/H2-antihistaminic action of omega-[2-aryl-2,3-dihydro-4(1H)-quinazolinone-1-yl]alkyl substituted ureas and cyanoguanidines].
May 1991, Archiv der Pharmazie,
R V Coombs, and R P Danna, and M Denzer, and G E Hardtmann, and B Huegi, and G Koletar, and J Koletar, and H Ott, and E Jukniewicz, and J W Perrine, and E I Takesue, and J H Trapold
N-(2-Aminobenzoyl)benzotriazole Mediated Synthesis of 3-Acyl-2-alkyl(aryl)-4-hydroxyquinolines and 3-Acylamino-4(3H) quinazolinones.
January 2024, Turkish journal of chemistry,
R V Coombs, and R P Danna, and M Denzer, and G E Hardtmann, and B Huegi, and G Koletar, and J Koletar, and H Ott, and E Jukniewicz, and J W Perrine, and E I Takesue, and J H Trapold
Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.
January 1990, Journal of medicinal chemistry,
R V Coombs, and R P Danna, and M Denzer, and G E Hardtmann, and B Huegi, and G Koletar, and J Koletar, and H Ott, and E Jukniewicz, and J W Perrine, and E I Takesue, and J H Trapold
Lithiation of 2-Alkyl-3-amino- and 2-Alkyl-3-(methylamino)-4(3H)-quinazolinones(1).
January 1996, The Journal of organic chemistry,
Copied contents to your clipboard!