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The bronchodilator action and cardiovascular toxicity of aerosols of (1) isoetharine, (2) isoetharine in combination with phenylephrine, (3) isoproterenol, and (4) phenylephrine were compared in a group of severe stable ambulatory asthmatics. All preparations except phenylephrine produced reduction in specific airway resistance and increased flow rates which peaked at 15 minutes. The action of isoproterenol and the two isoetharine preparations peaked at 15 minutes while the peak effect of isoetharine and isoetharine in combination with phenylephrine continued for 60 minutes. The difference between isoproterenol and isoetharine alone or in combination with phenylephrine was not statistically significant. None of the drugs produced any cardiovascular side effects. The authors conclude that isoetharine, though less potent than isoproterenol on a weight-for-weight basis, is an effective and safe bronchodilator. Addition of phenylephrine to isoetharine does not potentiate or prolong the action of the latter.
J Kaimal, and
H J Schwartz, and
E H Chester
January 1983,
Journal of clinical pharmacology,
J Kaimal, and
H J Schwartz, and
E H Chester
December 1977,
Chest,
J Kaimal, and
H J Schwartz, and
E H Chester
February 1967,
Diseases of the chest,
J Kaimal, and
H J Schwartz, and
E H Chester
April 1982,
Annals of allergy,
J Kaimal, and
H J Schwartz, and
E H Chester
January 1977,
Journal of clinical pharmacology,
J Kaimal, and
H J Schwartz, and
E H Chester
September 1981,
Chest,
J Kaimal, and
H J Schwartz, and
E H Chester
December 1981,
The Journal of the Association of Physicians of India,
J Kaimal, and
H J Schwartz, and
E H Chester
April 1983,
Annals of allergy,
J Kaimal, and
H J Schwartz, and
E H Chester
August 1971,
Chest,
J Kaimal, and
H J Schwartz, and
E H Chester
March 1967,
The American journal of the medical sciences,
