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An index of permeability of the alveolar-capillary membrane was derived from the relative extraction from the lung into arterial blood of 2 tracers, 125I-antipyrine and 51Cr-ethylenediaminetetraacetate. The effect on this index of aspirating 2 ml of isotonic saline, distilled water, or 10(-1) M hydrochloric acid per kg of body weight was studied in 3 groups of rabbits. The severity and time course of changes in the permeability index were correlated with changes in lung mechanics, gas exchange, serial chest roentgenograms, ratio of extravascular lung water to dry weight, and histologic findings. Aspiration of saline produced no change in the permeability index; aspiration of water produced a large mean +/- SEM increase in the index, from a baseline of 0.025 +/- 0.002 to 1,050 +/- 0.054 (P less than 0.001), but this value returned to baseline 15 min later. After hydrochloric acid, the permeability index increased from a baseline of 0.027 +/- 0.003 to 1.068 +/- 0.098 (P less than 0.005), with no evidence of resolution after 60 min. Changes in lung mechanics, gas exchange, and roentgenograms were smallest after aspiration of distilled water and greatest after aspiration of hydrochloric acid. The functional changes after aspiration of water and saline recovered at a rate proportional to the known clearance rates of these liquids from the lung. The changes after hydrochloric acid either showed no tendency toward recovery or, in the case of the roentgenograms, worsened with time. There were no detectable histologic abnormalities or an increase in the ratio of extravascular lung water to dry weight after aspiration of water or saline, but there were extensive histologic abnormalities and a 70 per cent increase in lung water after acid. The increase in the permeability index after aspiration of water was too transient to exert a deleterious effect. In contrast, the persistence of the increase in the permeability index after hydrochloric acid was associated with persistent functional changes attributable to the considerable increase in lung water.
J G Jones, and
R F Grossman, and
M Berry, and
G Slavin, and
G H Hulands, and
B Minty
January 1977,
Circulatory shock,
J G Jones, and
R F Grossman, and
M Berry, and
G Slavin, and
G H Hulands, and
B Minty
July 1981,
Japanese journal of medicine,
J G Jones, and
R F Grossman, and
M Berry, and
G Slavin, and
G H Hulands, and
B Minty
April 1974,
Aerospace medicine,
J G Jones, and
R F Grossman, and
M Berry, and
G Slavin, and
G H Hulands, and
B Minty
August 1979,
Chest,
J G Jones, and
R F Grossman, and
M Berry, and
G Slavin, and
G H Hulands, and
B Minty
February 1994,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
J G Jones, and
R F Grossman, and
M Berry, and
G Slavin, and
G H Hulands, and
B Minty
October 1981,
Journal of applied physiology: respiratory, environmental and exercise physiology,
J G Jones, and
R F Grossman, and
M Berry, and
G Slavin, and
G H Hulands, and
B Minty
September 1985,
British journal of industrial medicine,
J G Jones, and
R F Grossman, and
M Berry, and
G Slavin, and
G H Hulands, and
B Minty
January 1974,
Annals of the New York Academy of Sciences,
J G Jones, and
R F Grossman, and
M Berry, and
G Slavin, and
G H Hulands, and
B Minty
December 1978,
The American review of respiratory disease,
J G Jones, and
R F Grossman, and
M Berry, and
G Slavin, and
G H Hulands, and
B Minty
February 1980,
The Journal of surgical research,
