Biomaterial Database

[Hyaluronic acid in pleural fluids: an additional parameter for clinical diagnosis on diffuse mesotheliomas (author's transl)]. 1979

W Matzel, and G Schubert

187 pleural fluids of various etiology are examined with the intention to find hyaluronic acid. The colorimetric method of Morgan-Elson was used for this purpose. The mucopolysaccharid was identified in 34 cases: 18 in 30 cases of diffuse mesotheliomas 1 in 74 cases of secondary tumours of the pleura 8 in 20 cases of tuberculous pleurisy 5 in 37 cases of nonspecific pleurisy 2 in 6 cases of purulent pleursy. A level from more than 212 mg/litre was detected in 10 cases of mesotheliomas only. Such a concentration is consequently the proof for diffuse mesothelioma. The diagnostical improvement in other cases of mesotheliomas resulted from a combination of the following parameters: coagulation of protein by the method of Weltmann, cytological investigation of cellsedimentation and measurement of hyaluronic acid. Our experience with the diagnosis of diffuse mesotheliomas is discussed also in account to the results which are published since 1965 from a scientific team working in Lille, France, reporting the value of detection and measurement on hyaluronic acid in pleural fluids.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008654	Mesothelioma	A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)	Mesotheliomas
D009362	Neoplasm Metastasis	The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	Metastase,Metastasis,Metastases, Neoplasm,Metastasis, Neoplasm,Neoplasm Metastases,Metastases
D010996	Pleural Effusion	Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.	Effusion, Pleural,Effusions, Pleural,Pleural Effusions
D010997	Pleural Neoplasms	Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.	Neoplasms, Pleural,Neoplasm, Pleural,Pleural Neoplasm
D010998	Pleurisy	INFLAMMATION of PLEURA, the lining of the LUNG. When PARIETAL PLEURA is involved, there is pleuritic CHEST PAIN.	Pleuritis,Pleurisies,Pleuritides
D004653	Empyema	Presence of pus in a hollow organ or body cavity.
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006820	Hyaluronic Acid	A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.	Amo Vitrax,Amvisc,Biolon,Etamucine,Healon,Hyaluronan,Hyaluronate Sodium,Hyvisc,Luronit,Sodium Hyaluronate,Acid, Hyaluronic,Hyaluronate, Sodium,Vitrax, Amo