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Myocardial-necrosis was produced in two groups of albino rats by subcutaneous injection of isoprenaline in doses of 85 mg/kg and 42.5 mg/kg. The necrosis was confirmed by ECG changes, increased serum activities of AspAT, AlAT, GPT and LDH, and by histological examination. Myocardial manganese after isoprenaline administration was estimated over a period of 5 days. The decrease in myocardial manganese was proportional to the extent of cardiac damage. The possible mechanisms and the importance of these changes are discussed.
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