Biomaterial Database

Effect of diet on dichlorovinyl dimethyl phosphate toxicity in rats. 1979

T Purshottam, and U Kaveeshwar

Young male albino rats (120+/-5 g) were kept for 30 d on the following synthetic diets--High Protein Diet (HPD): 59% casein; Low Protein Diet (LPD): 5% casein; High Fat Diet (HFD): 51% fat; and Standard Diet (SD); 19% casein, 11% fat, and 60% sucrose. Composition of diet per se did not significantly affect plasma and RBC cholinesterase (ChE) activity, Mortality of animals on different diets, due to administration of DDVP (Vapona, dichlorovos) 50 mg/kg i.p. was: SD: 37%; HPD: 26.5%, LPD: 53%; and HFD: 44%. Plasma ChE inhibition after 24 h of DDVP administration (in surviving animals) was SD: 42%; HPD: 52%; LPD: 55%; and HFD: 47%. Erythrocyte ChE inhibition was 40% in SD, HPD, and HFD and 60% in the LPD rats. Five days following DDVP administration, plasma ChE was normal and erythrocyte ChE was still significantly increased and erythrocyte ChE was normal.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D002800	Cholinesterase Inhibitors	Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.	Acetylcholinesterase Inhibitor,Acetylcholinesterase Inhibitors,Anti-Cholinesterase,Anticholinesterase,Anticholinesterase Agent,Anticholinesterase Agents,Anticholinesterase Drug,Cholinesterase Inhibitor,Anti-Cholinesterases,Anticholinesterase Drugs,Anticholinesterases,Cholinesterase Inhibitors, Irreversible,Cholinesterase Inhibitors, Reversible,Agent, Anticholinesterase,Agents, Anticholinesterase,Anti Cholinesterase,Anti Cholinesterases,Drug, Anticholinesterase,Drugs, Anticholinesterase,Inhibitor, Acetylcholinesterase,Inhibitor, Cholinesterase,Inhibitors, Acetylcholinesterase,Inhibitors, Cholinesterase,Inhibitors, Irreversible Cholinesterase,Inhibitors, Reversible Cholinesterase,Irreversible Cholinesterase Inhibitors,Reversible Cholinesterase Inhibitors
D002802	Cholinesterases		Acylcholineacylhydrolase,Cholase,Cholinesterase
D004006	Dichlorvos	An organophosphorus insecticide that inhibits ACETYLCHOLINESTERASE.	DDVP,Dichlofos,Dichlorophos,Dimethyl Dichlorovinyl Phosphate,Divipan,Novotox,Phosphoric acid 2,2-dichloroethenyl dimethyl ester,Phosphoric acid 2,2 dichloroethenyl dimethyl ester
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D006128	Growth	Gradual increase in the number, the size, and the complexity of cells of an individual. Growth generally results in increase in ORGAN WEIGHT; BODY WEIGHT; and BODY HEIGHT.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus