Serum antibiotic concentrations pre- and postcardiopulmonary bypass. 1973

R M Kluge, and F M Calia, and J S McLaughlin, and R B Hornick

Serum concentrations of cephalothin or kanamycin, or both, were determined in 53 patients undergoing cardiopulmonary bypass. Conventional doses of these antibiotics did not provide serum levels above the accepted minimum inhibitory concentrations in children. Adults had adequate serum antibiotic concentrations only when the antimicrobials were administered within 4 h of beginning cardiopulmonary bypass. The impact of these variations upon the occurrence of infectious endocarditis could not be appraised since no cases of infective endocarditis were seen during a 4-month postoperative period.

UI MeSH Term Description Entries
D007612 Kanamycin Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components. Kanamycin A,Kanamycin Sulfate,Kantrex
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002512 Cephalothin A cephalosporin antibiotic. Cefalotin,Sodium Cephalothin,Cefalotina Normon,Cefalotina Sodica Spaly,Ceftina,Cephalothin Monosodium Salt,Keflin,Seffin,Cephalothin, Sodium,Monosodium Salt, Cephalothin,Salt, Cephalothin Monosodium
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004697 Endocarditis, Bacterial Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use. Bacterial Endocarditides,Bacterial Endocarditis,Endocarditides, Bacterial
D005112 Extracorporeal Circulation Diversion of blood flow through a circuit located outside the body but continuous with the bodily circulation. Circulation, Extracorporeal,Circulations, Extracorporeal,Extracorporeal Circulations
D005260 Female Females

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