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1 Aryl hydrocarbon hydroxylase (AHH), a mixed-function oxidase system, has been identified in microsomal preparations of adult breast skin and foreskin. 2 Separation of dermis from epidermis by stretching, showed that AHH activity in human skin is almost exclusively located within the epidermis. 3 Preincubation of whole chopped skin with benzanthracene (5 muM to 100 muM) using a tissue culture system was accompanied by a concentration dependent increase in AHH activity. 4 Although there was no significant difference in AHH activity between the two sites, individuals differed markedly from one another in activity at any one site. Activity was observed to be positively correlated with age.
P H Chapman, and
M D Rawlins, and
S Shuster
March 1984,
The British journal of dermatology,
P H Chapman, and
M D Rawlins, and
S Shuster
January 1973,
Drug metabolism and disposition: the biological fate of chemicals,
P H Chapman, and
M D Rawlins, and
S Shuster
November 1978,
The Journal of clinical investigation,
P H Chapman, and
M D Rawlins, and
S Shuster
December 1976,
The Journal of investigative dermatology,
P H Chapman, and
M D Rawlins, and
S Shuster
January 1982,
Toxicology,
P H Chapman, and
M D Rawlins, and
S Shuster
October 1989,
Environmental research,
P H Chapman, and
M D Rawlins, and
S Shuster
July 1981,
Cancer research,
P H Chapman, and
M D Rawlins, and
S Shuster
March 1981,
Chemico-biological interactions,
P H Chapman, and
M D Rawlins, and
S Shuster
June 1983,
Biochemical pharmacology,
P H Chapman, and
M D Rawlins, and
S Shuster
January 1983,
Placenta,
