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The possible use of liposomes (phospholipid vesicles) to direct cytotoxic drugs to tumours has led us to investigate the tissue localization of i.v. injected 99m-Tc-labelled liposomes in cancer patients. Twenty mg or 300 mg doses of liposomal lipid (7:2:1 molar ratio of phosphatidylcholine : cholesterol : phosphatidic acid) were used in a study of 13 patients with advanced cancer and one with polycythaemia rubra vera (PRV). In all cases except the patient with PRV the major site of uptake of the label was the liver and spleen. In the patient with PRV the liver uptake was greatly reduced and the major site of uptake was found in regions corresponding to marrow. With the exception of one patient with a primary hepatoma, there was no significant tumour uptake of the label.
V J Richardson, and
B E Ryman, and
R F Jewkes, and
K Jeyasingh, and
M N Tattersall, and
E S Newlands, and
S B Kaye
June 1997,
Annals of the rheumatic diseases,
V J Richardson, and
B E Ryman, and
R F Jewkes, and
K Jeyasingh, and
M N Tattersall, and
E S Newlands, and
S B Kaye
January 1987,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
V J Richardson, and
B E Ryman, and
R F Jewkes, and
K Jeyasingh, and
M N Tattersall, and
E S Newlands, and
S B Kaye
April 1968,
The Journal of obstetrics and gynaecology of the British Commonwealth,
V J Richardson, and
B E Ryman, and
R F Jewkes, and
K Jeyasingh, and
M N Tattersall, and
E S Newlands, and
S B Kaye
July 1985,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
V J Richardson, and
B E Ryman, and
R F Jewkes, and
K Jeyasingh, and
M N Tattersall, and
E S Newlands, and
S B Kaye
March 2012,
Equine veterinary journal,
V J Richardson, and
B E Ryman, and
R F Jewkes, and
K Jeyasingh, and
M N Tattersall, and
E S Newlands, and
S B Kaye
November 2001,
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
V J Richardson, and
B E Ryman, and
R F Jewkes, and
K Jeyasingh, and
M N Tattersall, and
E S Newlands, and
S B Kaye
January 1969,
Acta obstetricia et gynecologica Scandinavica,
V J Richardson, and
B E Ryman, and
R F Jewkes, and
K Jeyasingh, and
M N Tattersall, and
E S Newlands, and
S B Kaye
August 1993,
Die Pharmazie,
V J Richardson, and
B E Ryman, and
R F Jewkes, and
K Jeyasingh, and
M N Tattersall, and
E S Newlands, and
S B Kaye
January 2008,
Medical principles and practice : international journal of the Kuwait University, Health Science Centre,
V J Richardson, and
B E Ryman, and
R F Jewkes, and
K Jeyasingh, and
M N Tattersall, and
E S Newlands, and
S B Kaye
April 1968,
The Journal of obstetrics and gynaecology of the British Commonwealth,
