-transparent.png){kind=logo}
Experiments were carried out to test the hypothesis that the differences between the surfaces of erythrocytes from normal and sickle cell patients are reflected in the degree of attachment to the capillary lining. An assay was used that measured the number of 51Cr-labeled erythrocytes (normal or sickle) attaching to a monolayer of endothelium cultured from calf aortas. Under these conditions, erythrocytes from sickle cell patients adhered better to the endothelium than did those from normal patients. The results suggested that the enhanced adhesion of the sickle cells to the endothelium may be partially responsible for the increased blockage of capillaries that produce the symptoms in sickle cell anemia.
R Hoover, and
R Rubin, and
G Wise, and
R Warren
January 1996,
Blood,
R Hoover, and
R Rubin, and
G Wise, and
R Warren
July 1987,
Blood,
R Hoover, and
R Rubin, and
G Wise, and
R Warren
September 1982,
The Journal of laboratory and clinical medicine,
R Hoover, and
R Rubin, and
G Wise, and
R Warren
September 1987,
The Journal of clinical investigation,
R Hoover, and
R Rubin, and
G Wise, and
R Warren
November 2012,
American journal of physiology. Cell physiology,
R Hoover, and
R Rubin, and
G Wise, and
R Warren
March 2013,
Acta physiologica (Oxford, England),
R Hoover, and
R Rubin, and
G Wise, and
R Warren
January 2013,
PloS one,
R Hoover, and
R Rubin, and
G Wise, and
R Warren
September 2001,
Blood,
R Hoover, and
R Rubin, and
G Wise, and
R Warren
October 1995,
American journal of hematology,
R Hoover, and
R Rubin, and
G Wise, and
R Warren
October 1992,
Blood,
