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Eighty-nine patients with multiple myeloma resistant to melphalan were randomized to receive cyclophosphamide plus prednisone (CP) (47 patients) or cyclophosphamide plus BCNU plus prednisone (CBP) (42 patients). No differences were detected in the two groups prior to therapy. Objective responses occurred in three (7%) of the CP patients and in seven (17%) of the CBP patients. About 40% of the patients in each group achieved some response. Toxic reactions consisted mainly of leukopenia and thrombocytopenia. Median survival was not different in the two groups. The median survival time was 31 months among those patients with an objective response and 9.4 months among those without an objective response. The addition of BCNU to CP increased the frequency of objective response, but not significantly. This triple combination (CBP) cannot be recommended.
R A Kyle, and
S Gailani, and
B R Seligman, and
J Blom, and
O R McIntyre, and
T F Pajak, and
J F Holland
March 1982,
Cancer treatment reports,
R A Kyle, and
S Gailani, and
B R Seligman, and
J Blom, and
O R McIntyre, and
T F Pajak, and
J F Holland
January 1985,
Oncology,
R A Kyle, and
S Gailani, and
B R Seligman, and
J Blom, and
O R McIntyre, and
T F Pajak, and
J F Holland
February 1982,
Cancer treatment reports,
R A Kyle, and
S Gailani, and
B R Seligman, and
J Blom, and
O R McIntyre, and
T F Pajak, and
J F Holland
November 1982,
Cancer treatment reports,
R A Kyle, and
S Gailani, and
B R Seligman, and
J Blom, and
O R McIntyre, and
T F Pajak, and
J F Holland
May 1985,
Revista clinica espanola,
R A Kyle, and
S Gailani, and
B R Seligman, and
J Blom, and
O R McIntyre, and
T F Pajak, and
J F Holland
January 1984,
The Netherlands journal of medicine,
R A Kyle, and
S Gailani, and
B R Seligman, and
J Blom, and
O R McIntyre, and
T F Pajak, and
J F Holland
December 1977,
The American journal of medicine,
R A Kyle, and
S Gailani, and
B R Seligman, and
J Blom, and
O R McIntyre, and
T F Pajak, and
J F Holland
June 1982,
Cancer treatment reports,
R A Kyle, and
S Gailani, and
B R Seligman, and
J Blom, and
O R McIntyre, and
T F Pajak, and
J F Holland
October 1986,
European journal of cancer & clinical oncology,
R A Kyle, and
S Gailani, and
B R Seligman, and
J Blom, and
O R McIntyre, and
T F Pajak, and
J F Holland
January 1992,
European journal of cancer (Oxford, England : 1990),
